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Surface-enhanced Resonance Raman Scattering Nanoprobe Ratiometry for Detecting Microscopic Ovarian Cancer via Folate Receptor Targeting
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Folate Receptors' Expression in Gliomas May Possess Potential Nanoparticle-Based Drug Delivery Opportunities

Eva McCord1,2, Shreya Pawar1,3, Tejaswi Koneru1,4

  • 1Use-inspired Biomaterials & Integrated Nano Delivery (U-BiND) Systems Laboratory, Department of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, Michigan 48201, United States.

ACS Omega
|February 24, 2021
PubMed

Insights

Targeted nanoparticles offer a promising approach to overcome the blood-brain barrier (BBB) and treat brain cancers. Folate receptors are key targets for delivering chemotherapy drugs effectively to brain tumors.

Area of Science:

  • Neuro-oncology
  • Nanomedicine
  • Drug Delivery Systems

Background:

  • Brain cancer affects thousands of adults and children annually.
  • Current FDA-approved chemotherapies for brain cancer have limited efficacy due to the tumor microenvironment and toxicity.
  • The blood-brain barrier (BBB) significantly impedes drug delivery to brain tumors.

Purpose of the Study:

  • To review the application of folate receptors in targeted nanoparticle drug delivery for brain cancer treatment.
  • To explore strategies for overcoming the BBB using nanotechnology.

Main Methods:

  • Review of existing literature on folate receptors and nanoparticle drug delivery.
  • Analysis of the role of the tumor microenvironment and BBB in treatment efficacy.
  • Discussion of targeted delivery systems utilizing folate receptors.

Main Results:

  • Folate receptors are identified as highly useful targets for brain drug delivery.
  • Targeted nanoparticulate systems show potential for traversing the BBB.
  • Selective targeting of tumor cells by nanoparticles can enhance treatment outcomes.

Conclusions:

  • Targeted nanoparticles offer a viable strategy to improve brain cancer treatment by overcoming BBB limitations.
  • Folate receptor-targeted nanodrug delivery systems represent a promising therapeutic avenue for brain malignancies.

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