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Creatine kinase immunoreactivity: localization in nerve terminals in the hypothalamic area and superior colliculus of
1Department of Neuropathology, Faculty of Medicine, University of Tokyo, Japan.
Abstract:
Immunoperoxidase studies of mouse brain using antibody to creatine kinase (CK) revealed the presence of immunoreactive neuronal varicosities in the zona incerta, lateral hypothalamic area, arcuate nucleus and superior colliculus. In the zona incerta and lateral hypothalamic area, the varicosities were distributed among the distinctive CK-immunoreactive neurons and some varicosities apparently emerged from these neurons. In the arcuate nucleus, the varicosities were concentrated in the periventricular region and occasionally clustered around unstained neurons. In serial sections, a portion of varicosities could be traced from the lateral hypothalamic area to the arcuate nucleus. In the superior colliculus, CK immunoreactivity formed a network pattern, which was mainly confined to the stratum zonale and stratum griseum superficiale.