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Biocatalysis in Continuous-Flow Microfluidic Reactors.

Marco P Cardoso Marques1, Alvaro Lorente-Arevalo2, Juan M Bolivar3

  • 1Department of Biochemical Engineering, University College London, London, UK. marco.marques@ucl.ac.uk.

Advances in Biochemical Engineering/Biotechnology
|February 24, 2021
PubMed
Summary
This summary is machine-generated.

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Continuous-flow biocatalysis using microfluidic reactors offers significant advantages for bioprocess development and reaction scale-up. Overcoming current challenges will establish flow biocatalysis as a universal tool.

Area of Science:

  • Biocatalysis
  • Chemical Engineering
  • Microfluidics

Background:

  • Continuous-flow biocatalysis has gained significant attention recently.
  • Flow microfluidic reactors are key technologies driving this trend.
  • These reactors offer improvements in bioprocess development, reaction intensification, screening, and scale-up.

Purpose of the Study:

  • To provide an overview of flow biocatalysis applications.
  • To discuss applications based on enzyme form (free vs. immobilized).
  • To identify challenges and limitations for universal adoption.

Main Methods:

  • Review of existing literature on flow biocatalysis.
  • Categorization of applications by enzyme form.
  • Analysis of challenges and limitations.
Keywords:
Continuous productionEnzyme immobilizationFlow biocatalysisMicrofluidic reactorsMiniaturizationReaction intensification

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Main Results:

  • Flow biocatalysis shows promise across various bioprocess levels.
  • Applications differ based on whether free or immobilized enzymes are used.
  • Current implementation is often case-by-case.

Conclusions:

  • Synergy between biocatalysis and microfluidic reactor design is crucial.
  • Addressing current limitations is necessary for widespread adoption.
  • The goal is to make continuous-flow microfluidic reactors a universal tool in biocatalysis.