Hypophysectomy in monosodium glutamate-pretreated rats suppresses paradoxical sleep rebound

¹Laboratoire de Médecine Expérimentale, INSERM U52, C.N.R.S. UA1195, Université Claude Bernard, Lyon France.

|March 21, 1988

Abstract:

Control untreated and pretreated female rats at birth with 10 injections of monosodium glutamate (MSG, 4 mg/g b. wt.) were hypophysectomized (HYPX) at 45-60 days of age and their sleep-waking cycle continuously registered. In control rats, hypophysectomy was followed by a 35.7% decrease in paradoxical sleep (PS) duration while it has no effect on the sleep of MSG-treated rats. After 24 h of PS deprivation, there was a normal immediate rebound of PS in the control HYPX and MSG rats while there was no significant rebound in the HYPX-MSG-treated rats. It is concluded that neuropeptides from arcuate nucleus and hypophysis are involved in a PS rebound mechanism.

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