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Standardization of experimental model regarding star fruit intoxication in Wistar rats suffering with nephropathy
Layla Alves Rodrigues da Silva1, Renato Figueiredo Santana2, Eduardo Achar3
1Fellow Master Degree. Instituto de Assistência Médica ao Servidor Público Estadual - Postgraduate Program in Health Science - São Paulo (SP), Brazil.
Purpose:
To present a model to reproduce the clinical condition, in order to better understand the pathophysiology of neurological impairment related to intoxication.
Methods:
Twenty-five Wistar rats were used and divided into five groups: Shaw group (WHI), water gavage group (WGV), star fruit gavage group (SGV), nephropathic group with water gavage (NPW), nephropathic group with star fruit gavage (NPS).Nephropathic groups were submitted to surgery, developing nephropathy. After surgery, they received preestablished gavage with star fruit juice or water. The electroencephalographic records were evaluated in the experimental nephropathic group that received gavage of star fruit juice.
Results:
To assess the induction of neurotoxicity using electroencephalographic data, the NPS group demonstrated the presence of epileptic seizures associated with star fruit intoxication.
Conclusions:
The experimental model herein presented was adequate to reproduce the clinical condition experienced by nephropathic patients who ingest star fruit juice, establishing, thus, an experimental model utterly important for the study of the neurological toxicity process.
