Vagotomy associated with splenectomy reduces lipid accumulation and causes kidneys histological changes in rats with hypothalamic obesity
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Updated: Nov 16, 2025
Rat Model of the Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy ALPPS Procedure
Published on: August 14, 2017
Kamila Aparecida Medeiros1, Bruna Schumaker Siqueira2, Marianela Andrea Díaz Urrutia3
1MSc. Universidade Estadual do Oeste do Paraná - Health Sciences Center - Postgraduate Program in Applied Health Sciences - Francisco Beltrão (PR), Brazil.
Purpose:
To evaluate the influence of autonomic vagal and splenic activities on renal histomorphometric aspects in obese rats.
Methods:
Thirty male Wistar rats were used, of which, 24 received subcutaneous injections of monosodium glutamate (MSG) during the first 5 days of life (4 g/kg body weight) and six control animals received injections of saline solution (CON). Five experimental groups were organized (n = 6/group): falsely-operated control (CON-FO); falsely-operated obese (MSG-FO); vagotomized obese (MSG-VAG); splenectomized obese (MSG-SPL); vagotomized and splenectomized obese (MSG-VAG-SPL).
Results:
The MSG-FO group animals showed a significant reduction in body weight and nasal-anal length when compared to CON-FO group animals (p < 0.05). The MSG-VAG-SPL group showed significant reduced in most biometric parameters associated with obesity. Falsely-operated obese animals showed a significant reduction in renal weight, glomerular diameters, glomerular tuff and capsule areas and Bowman's space compared to CON-FO group animals (p < 0.05). There was a significant reduction in diameter, glomerular tuft and capsule areas, and Bowman's space in MSG-VAG, MSG-SPL, MSG-VAG-SPL groups when compared to the MSG-FO group.
Conclusions:
Vagotomy associated with splenectomy induces a reduction in the adiposity and causes histological changes in the kidney of obese rats.
