Related Experiment Video
Updated: Nov 16, 2025
Rat Model of the Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy ALPPS Procedure
Published on: August 14, 2017
Vagotomy associated with splenectomy reduces lipid accumulation and causes kidneys histological changes in rats with
Kamila Aparecida Medeiros1, Bruna Schumaker Siqueira2, Marianela Andrea Díaz Urrutia3
1MSc. Universidade Estadual do Oeste do Paraná - Health Sciences Center - Postgraduate Program in Applied Health Sciences - Francisco Beltrão (PR), Brazil.
Purpose:
To evaluate the influence of autonomic vagal and splenic activities on renal histomorphometric aspects in obese rats.
Methods:
Thirty male Wistar rats were used, of which, 24 received subcutaneous injections of monosodium glutamate (MSG) during the first 5 days of life (4 g/kg body weight) and six control animals received injections of saline solution (CON). Five experimental groups were organized (n = 6/group): falsely-operated control (CON-FO); falsely-operated obese (MSG-FO); vagotomized obese (MSG-VAG); splenectomized obese (MSG-SPL); vagotomized and splenectomized obese (MSG-VAG-SPL).
Results:
The MSG-FO group animals showed a significant reduction in body weight and nasal-anal length when compared to CON-FO group animals (p < 0.05). The MSG-VAG-SPL group showed significant reduced in most biometric parameters associated with obesity. Falsely-operated obese animals showed a significant reduction in renal weight, glomerular diameters, glomerular tuff and capsule areas and Bowman's space compared to CON-FO group animals (p < 0.05). There was a significant reduction in diameter, glomerular tuft and capsule areas, and Bowman's space in MSG-VAG, MSG-SPL, MSG-VAG-SPL groups when compared to the MSG-FO group.
Conclusions:
Vagotomy associated with splenectomy induces a reduction in the adiposity and causes histological changes in the kidney of obese rats.
