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Puerarin plays a protective role in chondrocytes by activating Beclin1-dependent autophagy

Guishuang Li¹, Hongming Rao¹, Weihong Xu¹

¹Department of orthopedics, The First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, China.

Bioscience, Biotechnology, and Biochemistry

|February 24, 2021

Abstract:

Puerarin can protect chondrocytes, whereby ameliorating osteoarthritis. Puerarin also promotes autophagy. Autophagy maintains chondrocyte homeostasis. The role of autophagy in puerarin-protected chondrocytes is unknown. Puerarin promoted chondrocyte autophagy. Puerarin-protected chondrocytes were reversed by autophagy inhibitors and Beclin1 inhibitor. 3-MA or Beclin1 inhibitor in vivo reversed puerarin-ameliorated cartilage damage of osteoarthritis mice. Thus, puerarin can protect chondrocytes through Beclin1-dependent autophagy activation.

Keywords:

Beclin1 Puerarin autophagy chondrocyte osteoarthritis

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