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Updated: Nov 16, 2025

Cutaneous Leishmaniasis in the Dorsal Skin of Hamsters: a Useful Model for the Screening of Antileishmanial Drugs

Cutaneous Leishmaniasis in the Dorsal Skin of Hamsters: a Useful Model for the Screening of Antileishmanial Drugs

Published on: April 21, 2012

Leishmaniasis in Norway.

Karl Erik Müller, Bjørn Blomberg, Marit Gjerde Tellevik

Tidsskrift for Den Norske Laegeforening : Tidsskrift for Praktisk Medicin, Ny Raekke

|February 24, 2021

Summary

This summary is machine-generated.

Norwegian clinicians diagnosed 13 leishmaniasis cases between 2014-2017. Late diagnosis occurred due to unfamiliarity, but liposomal amphotericin B proved effective for visceral and cutaneous leishmaniasis.

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Area of Science:

Tropical infectious diseases
Parasitology
Clinical diagnostics

Background:

Leishmaniasis is a rare tropical disease, often unfamiliar to Norwegian clinicians.
This study addresses diagnosis and treatment challenges in Norway.

Purpose of the Study:

To investigate leishmaniasis case numbers, diagnostic performance, and treatment outcomes.
To assess clinical management of leishmaniasis in Norwegian university hospitals.

Main Methods:

Prospective registration of suspected leishmaniasis cases from March 2014 to September 2017.
Involved five Norwegian university hospitals: Bergen, Oslo, Stavanger, Trondheim, and Tromsø.
Diagnostic methods included serology, microscopy, and PCR; treatments were documented.

Main Results:

13 leishmaniasis patients were identified: 2 visceral, 11 cutaneous.
Visceral leishmaniasis patients, infected in the Mediterranean, were diagnosed late but responded to liposomal amphotericin B.
Cutaneous leishmaniasis was primarily diagnosed via PCR; liposomal amphotericin B was first-line treatment.

Conclusions:

Late diagnosis of leishmaniasis in Norway is linked to disease rarity and clinician unfamiliarity.
Effective treatment options exist, but challenges in drug availability and administration knowledge persist for cutaneous leishmaniasis.
Standardized diagnostic and treatment protocols are needed for better patient outcomes.