Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Analgesia and Pain Management01:25

Analgesia and Pain Management

1.1K
Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
1.1K
Opioid Analgesics: Synthetic and Semisynthetic Opioids01:15

Opioid Analgesics: Synthetic and Semisynthetic Opioids

649
Synthetic and semisynthetic opioids are pivotal in pain management and tackling opioid addiction. Semisynthetic opioids, including morphinans (morphine derivatives), oxycodone, oxymorphone, hydrocodone, and hydromorphone, have improved pharmacokinetic profiles compared to morphine. Additionally, heroin and 6-MAM (6-Monoacetylmorphine) show better CNS penetration than morphine due to heightened lipid solubility. Hydromorphone, a potent opioid, undergoes hepatic metabolism to form the active...
649
Opioid Analgesics: Morphine and Other Natural Cogeners01:20

Opioid Analgesics: Morphine and Other Natural Cogeners

577
Opioids are a class of drugs that mimic endogenous opioid peptides and act on opioid receptors, and help in pain relief. These compounds are classified as natural, synthetic, or semi-synthetic. Natural opioids, like morphine, codeine, and thebaine, are derived from the opium poppy plant (Papaver somniferum or Papaver album) and are termed opiates. Synthetic opioids are artificial, while semi-synthetic opioids combine natural and synthetic compounds. Morphine, a prototypical opioid, possesses a...
577
Opioid Receptors: Overview01:22

Opioid Receptors: Overview

3.1K
Opioid receptors, including the mu (μ, MOR), delta (δ, DOR), and kappa (κ, KOR) types, belong to the rhodopsin family of G protein-coupled receptors. These receptors are located throughout the central and peripheral nervous systems and in non-neuronal tissues such as macrophages and astrocytes. Opioid receptor ligands can be categorized into agonists or antagonists. Highly selective agonists include [d-Ala2, MePhe4, Gly(ol)5]-enkephalin or DAMGO for MOR, [D-Pen2,...
3.1K
Dosage Regimens: Designs and Approaches01:28

Dosage Regimens: Designs and Approaches

117
Designing a dosage regimen, which refers to the manner of drug administration, is a complex process involving the selection of drug dose, route, and frequency. This process is underpinned by pharmacokinetic parameters derived from tests and population averages. These parameters are then tailored to patient-specific variables such as diagnosis, demographics, and allergy status. Once therapy commences, therapeutic response monitoring is critical and achieved through clinical and physical...
117
Drugs Affecting GI Tract Motility: Opioids as Antidiarrheal Agents01:17

Drugs Affecting GI Tract Motility: Opioids as Antidiarrheal Agents

462
Diarrhea, a condition marked by frequent loose or watery bowel movements, can be triggered by multiple factors such as viral or bacterial infections, food intolerances, anxiety, medications, and digestive disorders. Symptoms may include abdominal pain, bloating, nausea, and cramping. Severe or prolonged diarrhea can lead to complications like electrolyte imbalances, malnutrition, and dehydration if left untreated.
Opioids, widely used antidiarrheal agents, mitigate diarrhea by slowing down...
462

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Disentangling the unique associations of age, pubertal stage, and pubertal hormones with white matter microstructure in childhood and adolescence.

Imaging neuroscience (Cambridge, Mass.)·2026
Same author

A Cross-Sectional Street Survey Examining a Preference for Truth-Telling in Serious Illness and End-of-Life in Maputo City Province.

Journal of palliative medicine·2026
Same author

Vertexwise Cortical Deviation Mapping (VCDM): A precision approach to cortical thickness assessment in non-affective psychosis.

Brain imaging and behavior·2026
Same author

Functional network comparative area and topography analysis (FUNCATA) in non-affective psychosis: a replication study.

Schizophrenia (Heidelberg, Germany)·2026
Same author

A Window of Opportunity: Unraveling How Puberty Relates to Psychotic-Like Experiences During Adolescence.

Biological psychiatry global open science·2026
Same author

Lateralization of auditory steady state response (ASSR) deficits in first-episode schizophrenia - Effects of attention and associations with auditory hallucination severity.

Journal of psychiatric research·2025

Related Experiment Video

Updated: Nov 16, 2025

Determining Pain Detection and Tolerance Thresholds Using an Integrated, Multi-Modal Pain Task Battery
09:38

Determining Pain Detection and Tolerance Thresholds Using an Integrated, Multi-Modal Pain Task Battery

Published on: April 14, 2016

12.9K

Monitoring Equianalgesic Opioid Dosing.

Mark Curtis1, Mary Lynn McPherson, Stacy M Swagger

  • 1Mark Curtis is director of Integrative Medicine and Complimentary Care at Innovative Care Solutions, Dayton, OH. Mary Lynn McPherson is a professor at the University of Maryland School of Pharmacy, Baltimore. Stacy M. Swagger is executive director of Canon City Pregnancy Center, Canon City, CO. Marianne Matzo is an AJN contributing editor and coordinates Perspectives on Palliative Nursing . Contact author: Marianne Matzo, marianne@every1dies.org . The authors have disclosed no potential conflicts of interest, financial or otherwise.

The American Journal of Nursing
|February 24, 2021
PubMed
Summary

This series focuses on palliative care, emphasizing the Hospice and Palliative Nurses Association's (HPNA) role in guiding nurses. HPNA promotes optimal patient and family care, regardless of disease stage or treatment needs.

More Related Videos

Assessment of Morphine-induced Hyperalgesia and Analgesic Tolerance in Mice Using Thermal and Mechanical Nociceptive Modalities
07:23

Assessment of Morphine-induced Hyperalgesia and Analgesic Tolerance in Mice Using Thermal and Mechanical Nociceptive Modalities

Published on: July 29, 2014

33.8K
Use of the Operant Orofacial Pain Assessment Device OPAD to Measure Changes in Nociceptive Behavior
12:20

Use of the Operant Orofacial Pain Assessment Device OPAD to Measure Changes in Nociceptive Behavior

Published on: June 10, 2013

21.5K

Related Experiment Videos

Last Updated: Nov 16, 2025

Determining Pain Detection and Tolerance Thresholds Using an Integrated, Multi-Modal Pain Task Battery
09:38

Determining Pain Detection and Tolerance Thresholds Using an Integrated, Multi-Modal Pain Task Battery

Published on: April 14, 2016

12.9K
Assessment of Morphine-induced Hyperalgesia and Analgesic Tolerance in Mice Using Thermal and Mechanical Nociceptive Modalities
07:23

Assessment of Morphine-induced Hyperalgesia and Analgesic Tolerance in Mice Using Thermal and Mechanical Nociceptive Modalities

Published on: July 29, 2014

33.8K
Use of the Operant Orofacial Pain Assessment Device OPAD to Measure Changes in Nociceptive Behavior
12:20

Use of the Operant Orofacial Pain Assessment Device OPAD to Measure Changes in Nociceptive Behavior

Published on: June 10, 2013

21.5K

Area of Science:

  • Palliative Care Nursing
  • Healthcare Education

Background:

  • Palliative care aims to relieve suffering and enhance quality of life for patients and families.
  • The Hospice and Palliative Nurses Association (HPNA) is a key organization in advancing palliative care nursing.
  • Effective nursing guidance is crucial for comprehensive palliative care delivery.

Purpose of the Study:

  • To introduce a series on palliative care developed in collaboration with HPNA.
  • To highlight HPNA's mission in guiding nurses for optimal patient and family support.
  • To underscore the importance of palliative care across all disease stages and treatment modalities.

Main Methods:

  • Collaboration between palliative care experts and HPNA.
  • Development of an educational series for nurses.
  • Dissemination of best practices in palliative care.

Main Results:

  • A comprehensive series on palliative care is now available.
  • Nurses are provided with guidance for preventing and relieving suffering.
  • Focus on holistic care for patients and families is reinforced.

Conclusions:

  • The collaborative series enhances nursing capacity in palliative care.
  • HPNA's resources support evidence-based practice in palliative nursing.
  • Optimal patient and family outcomes are achievable through dedicated palliative care.