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Updated: Nov 16, 2025

Author Spotlight: Modeling an Aspect of Preeclampsia in Female Mice Using Hypoxic Human Placenta-Derived Small Extracellular Vesicles
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Author Spotlight: Modeling an Aspect of Preeclampsia in Female Mice Using Hypoxic Human Placenta-Derived Small Extracellular Vesicles

Published on: January 26, 2024

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CREB-binding protein (CREBBP) and preeclampsia: a new promising target gene

Hossein Sadeghi1, Sahra Esmkhani2,3, Reihaneh Pirjani4

  • 1Genomic Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Molecular Biology Reports
|February 24, 2021
PubMed

Insights

Preeclampsia (PE) involves higher CREBBP gene expression in placental tissue. This finding suggests CREBBP may play a role in PE development and could be a future therapeutic target.

Area of Science:

  • Obstetrics and Gynecology
  • Molecular Biology
  • Genetics

Background:

  • Preeclampsia (PE) is a significant pregnancy complication causing maternal and neonatal mortality.
  • Increased PE incidence is observed in pregnancies with fetal Rubinstein-Taybi Syndrome, linked to CREBBP gene mutations.

Purpose of the Study:

  • To compare CREBBP gene expression levels between preeclamptic and healthy placentas.
  • To investigate the differential expression of CREBBP in maternal versus fetal placental tissues.

Main Methods:

  • Quantitative real-time polymerase chain reaction (qRT-PCR) was used.
  • One hundred placental biopsies were analyzed from PE patients and healthy controls.
  • CREBBP expression was assessed in both maternal and fetal placental sides.

Main Results:

  • CREBBP gene expression was significantly higher in preeclamptic placentas compared to controls (Fold change = 2.158, P = 0.018).
  • A trend towards higher CREBBP expression was noted in the fetal placental side, but this difference was not statistically significant (Fold change = 1.713, P = 0.254).

Conclusions:

  • The study indicates a role for CREBBP in the pathogenesis of preeclampsia.
  • Given CREBBP's function in angiogenesis and hypoxia, it represents a potential target for future research and therapeutic strategies.

Keywords:
CREBBPExpression analysisPreeclampsia

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