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Impaired right ventricular filling in patients with a chronic coronary syndrome

Alexey N Sumin1, Ekaterina V Korok2, Tat'ana Yu Sergeeva3

  • 1Laboratory for Comorbidity in Cardiovascular Diseases, Federal State Budgetary Institution "Research Institute for Complex Issues of Cardiovascular Disease", Kemerovo, Russian Federation. an_sumin@mail.ru.

Medical Ultrasonography
|February 24, 2021
PubMed

Insights

Right ventricle diastolic dysfunction (RVDD) is common in coronary artery disease (CAD) patients, often linked to age and left ventricular dysfunction, not coronary lesions. Further research is needed to understand its predictive value.

Area of Science:

  • Cardiology
  • Echocardiography
  • Cardiovascular Disease

Background:

  • Right ventricle (RV) systolic dysfunction is well-documented in coronary artery disease (CAD).
  • Right ventricle diastolic dysfunction (RVDD) is less understood and investigated in CAD patients.
  • Assessing RVDD is crucial for a comprehensive understanding of RV function in CAD.

Purpose of the Study:

  • To determine the incidence of RVDD in patients with stable CAD.
  • To identify clinical and echocardiographic factors associated with the presence of RVDD.
  • To compare the prevalence of RVDD with RV systolic dysfunction in CAD.

Main Methods:

  • Echocardiographic assessment of RV diastolic parameters in 200 stable CAD patients.
  • Measurement of early (Et) and late (At) RV filling velocities and tricuspid annular velocities (et', a't, s't).
  • Comparison of RVDD (n=92) and non-RVDD (n=108) groups to identify associated factors.

Main Results:

  • RVDD was present in 46% of CAD patients, significantly more common than RV systolic dysfunction (7.5%).
  • Factors associated with RVDD included older age, prior myocardial infarction (MI), congestive heart failure, peripheral arterial disease, and reduced left ventricular ejection fraction (LVEF).
  • Coronary artery stenosis severity did not differ significantly between groups with and without RVDD.

Conclusions:

  • RVDD is highly prevalent in stable CAD patients.
  • RVDD is primarily associated with advanced age and left ventricular systolic dysfunction.
  • The independent prognostic value of RVDD in CAD warrants further investigation.
Abstract

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