Factors Associated With Increased Complications in Patients With BRCA Gene Mutations Undergoing Reconstructive Breast...

Area of Science:

• Oncology
• Plastic Surgery
• Genetics

Background:

• Bilateral prophylactic mastectomy with reconstruction is increasing in BRCA gene mutation carriers.
• Risk-reducing surgery offers significant benefits for young, high-risk patients.
• Limited evidence exists on complication rates and predictors in this population.

Purpose of the Study:

• To identify predictors of complications in BRCA gene mutation carriers undergoing reconstructive breast surgery.
• To evaluate factors associated with increased postoperative complications.

Main Methods:

• Single-center, retrospective cohort study.
• Included BRCA gene mutation carriers who underwent reconstructive breast surgery (immediate or delayed) between January 2013 and March 2019.
• Minimum 6 months of follow-up was required.

Main Results:

• Smoking identified as the most significant modifiable risk factor for complications.
• Smoking cessation can reduce postoperative complication risk by 50%.

Conclusions:

• Smoking cessation should be strongly encouraged and enforced for BRCA carriers undergoing prophylactic and reconstructive surgery.
• Addressing smoking is crucial for improving surgical outcomes in this patient group.