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Trace elements in patients with aortic valve sclerosis

Hataw Al-Taesh1, Abuzer Çelekli2, Murat Sucu3

  • 1Department of Biochemistry Science and Technology, Institute of Natural and Applied Sciences, Faculty of Arts and Science, Gaziantep University, Gaziantep, Turkey.

Therapeutic Advances in Cardiovascular Disease
|February 25, 2021
PubMed

Insights

Aortic valve sclerosis (AVSc) is linked to trace element imbalances. Patients with AVSc showed significantly lower serum zinc levels compared to healthy individuals, suggesting zinc

Area of Science:

  • Cardiology
  • Biochemistry
  • Trace Element Metabolism

Background:

  • Aortic valve sclerosis (AVSc) involves aortic valve thickening and calcification without outflow obstruction.
  • AVSc is associated with an imbalance in essential trace elements.

Purpose of the Study:

  • To investigate the relationship between AVSc and serum levels of iron (Fe), zinc (Zn), selenium (Se), and copper (Cu).
  • To explore the clinical significance of these trace elements as potential biomarkers for AVSc.
  • To clarify the pathophysiological role of these elements in AVSc development.

Main Methods:

  • A study involving 40 AVSc patients and a gender-matched healthy control group.
  • Echocardiography was used for AVSc diagnosis.
  • Serum concentrations of Zn and Cu were measured by atomic absorption spectroscopy; Se by ICP-MS; Fe by Beckman Coulter instrument.

Main Results:

  • AVSc patients exhibited significantly lower serum zinc (Zn) levels compared to controls (p < 0.01).
  • No significant differences were found in serum iron (Fe), selenium (Se), or copper (Cu) levels between groups (p > 0.05).
  • AVSc patients had higher prevalence of obesity, hypertension, and diabetes.

Conclusions:

  • Patients with AVSc demonstrate a trace element imbalance, notably lower serum zinc.
  • Serum zinc may serve as a potential biomarker for AVSc.
  • Obesity, hypertension, and diabetes are prevalent in AVSc patients, indicating complex multifactorial etiology.
Abstract

Keywords:
aortic valve sclerosiscopperironseleniumzinc

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