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DDX3X: structure, physiologic functions and cancer

Jie Mo1,2,3, Huifang Liang1,2,3, Chen Su1,2,3

  • 1Hubei Key Laboratory of Hepato-Pancreato-Biliary Diseases, Wuhan, Hubei, 430030, People's Republic of China.

Molecular Cancer
|February 25, 2021
PubMed

Insights

The DEAD-box helicase DDX3X protein impacts RNA metabolism and is crucial in cancer development. This review details DDX3X

Area of Science:

  • Molecular Biology
  • Genetics
  • Oncology

Background:

  • The DEAD-box helicase DDX3X (DBX, DDX3) is vital for RNA metabolism.
  • DDX3X is implicated in various diseases, including cancer, viral infections, and developmental disorders.

Purpose of the Study:

  • To review the multifaceted roles of DDX3X in biological processes.
  • To systematically analyze DDX3X's functions and mechanisms in tumorigenesis and cancer progression.

Main Methods:

  • Literature review synthesizing findings on DDX3X.
  • Analysis of DDX3X's involvement in RNA metabolism, stress responses, and cancer biology.

Main Results:

  • DDX3X regulates RNA metabolism, cellular stress, innate immunity, and embryonic development.
  • DDX3X plays significant roles in various cancer types, influencing tumorigenesis and progression.
  • Specific mechanisms and signaling pathways involving DDX3X in cancer are detailed.

Conclusions:

  • DDX3X is a key regulator with diverse functions in normal biology and disease.
  • Understanding DDX3X's role in cancer provides insights into therapeutic strategies.
Keywords:
CancerDDX3XRNA metabolism

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