Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Epigenetic Regulation01:37

Epigenetic Regulation

3.4K
Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
3.4K
Epigenetic Regulation01:46

Epigenetic Regulation

32.0K
Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
32.0K
Abnormal Proliferation02:23

Abnormal Proliferation

4.9K
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
4.9K
Cadherins in Tissue Organization01:19

Cadherins in Tissue Organization

3.5K
The cadherins are a superfamily of cell adhesion molecules comprising over 180 variants, with specific tissues expressing a particular combination of cadherin types. Cadherins generally exhibit homophilic binding; i.e., cadherins on one cell bind to cadherins of the same or closely related type on another cell. Thus, cells of the same type have a specific affinity to bind to each other and sort themselves into clusters to form tissues.
Cell Sorting During Development
Cell sorting plays an...
3.5K
Exon Recombination02:32

Exon Recombination

3.9K
The evolution of new genes is critical for speciation. Exon recombination, also known as exon shuffling or domain shuffling, is an important means of new gene formation. It is observed across vertebrates, invertebrates, and in some plants such as potatoes and sunflowers. During exon recombination, exons from the same or different genes recombine and produce new exon-intron combinations, which might evolve into new genes. 
Exon shuffling follows “splice frame rules.” Each exon...
3.9K
Adaptive Mechanisms in Cancer Cells02:53

Adaptive Mechanisms in Cancer Cells

6.2K
Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
6.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Outcomes of transanal vs laparoscopic total mesorectal excision for mid and low rectal cancer under routine clinical practice conditions.

Surgical endoscopy·2026
Same author

PET imaging of atherosclerotic plaques using the stabilin-2-targeted tracer <sup>18</sup>F-S2P in preclinical models.

European journal of nuclear medicine and molecular imaging·2026
Same author

When technology awakens willingness but stalls action: the asymmetric psychological translation of managerial safety cognition.

Frontiers in psychology·2026
Same author

LysePred: A Multiscale Convolutional Neural Network for Predicting Hemolytic Activity of Antimicrobial Peptides.

ACS synthetic biology·2026
Same author

EGCG inactivates tumor necrosis factor-alpha (TNFα) by inducing its higher-order assembly.

Phytomedicine : international journal of phytotherapy and phytopharmacology·2026
Same author

FcRL4 is an IgA receptor that primarily binds the joining chain.

Proceedings of the National Academy of Sciences of the United States of America·2026

Related Experiment Video

Updated: Nov 16, 2025

High-Throughput Dissociation and Orthotopic Implantation of Breast Cancer Patient-Derived Xenografts
06:06

High-Throughput Dissociation and Orthotopic Implantation of Breast Cancer Patient-Derived Xenografts

Published on: December 20, 2024

921

DDX3X: structure, physiologic functions and cancer.

Jie Mo1,2,3, Huifang Liang1,2,3, Chen Su1,2,3

  • 1Hubei Key Laboratory of Hepato-Pancreato-Biliary Diseases, Wuhan, Hubei, 430030, People's Republic of China.

Molecular Cancer
|February 25, 2021
PubMed
Summary
This summary is machine-generated.

The DEAD-box helicase DDX3X protein impacts RNA metabolism and is crucial in cancer development. This review details DDX3X

Keywords:
CancerDDX3XRNA metabolism

More Related Videos

Characterization of Cell Membrane Extensions and Studying Their Roles in Cancer Cell Adhesion Dynamics
08:11

Characterization of Cell Membrane Extensions and Studying Their Roles in Cancer Cell Adhesion Dynamics

Published on: March 26, 2018

8.6K
Mapping the Structure-Function Relationships of Disordered Oncogenic Transcription Factors Using Transcriptomic Analysis
09:58

Mapping the Structure-Function Relationships of Disordered Oncogenic Transcription Factors Using Transcriptomic Analysis

Published on: June 27, 2020

3.0K

Related Experiment Videos

Last Updated: Nov 16, 2025

High-Throughput Dissociation and Orthotopic Implantation of Breast Cancer Patient-Derived Xenografts
06:06

High-Throughput Dissociation and Orthotopic Implantation of Breast Cancer Patient-Derived Xenografts

Published on: December 20, 2024

921
Characterization of Cell Membrane Extensions and Studying Their Roles in Cancer Cell Adhesion Dynamics
08:11

Characterization of Cell Membrane Extensions and Studying Their Roles in Cancer Cell Adhesion Dynamics

Published on: March 26, 2018

8.6K
Mapping the Structure-Function Relationships of Disordered Oncogenic Transcription Factors Using Transcriptomic Analysis
09:58

Mapping the Structure-Function Relationships of Disordered Oncogenic Transcription Factors Using Transcriptomic Analysis

Published on: June 27, 2020

3.0K

Area of Science:

  • Molecular Biology
  • Genetics
  • Oncology

Background:

  • The DEAD-box helicase DDX3X (DBX, DDX3) is vital for RNA metabolism.
  • DDX3X is implicated in various diseases, including cancer, viral infections, and developmental disorders.

Purpose of the Study:

  • To review the multifaceted roles of DDX3X in biological processes.
  • To systematically analyze DDX3X's functions and mechanisms in tumorigenesis and cancer progression.

Main Methods:

  • Literature review synthesizing findings on DDX3X.
  • Analysis of DDX3X's involvement in RNA metabolism, stress responses, and cancer biology.

Main Results:

  • DDX3X regulates RNA metabolism, cellular stress, innate immunity, and embryonic development.
  • DDX3X plays significant roles in various cancer types, influencing tumorigenesis and progression.
  • Specific mechanisms and signaling pathways involving DDX3X in cancer are detailed.

Conclusions:

  • DDX3X is a key regulator with diverse functions in normal biology and disease.
  • Understanding DDX3X's role in cancer provides insights into therapeutic strategies.