Related Experiment Video
Updated: Nov 16, 2025
07:27
Implantation of Total Artificial Heart in Congenital Heart Disease
Published on: July 18, 2014
25.0K
Total Artificial Heart as Bridge to Cardiac Retransplantation
Ronit H Zadikany1, Robert M Cole, David H Chang
1From the Department of Cardiology, Department of Cardiothoracic Surgery, Smidt Heart Institute at Cedars-Sinai, Los Angeles, California.
ASAIO Journal (American Society for Artificial Internal Organs : 1992)
|February 25, 2021
Summary
Total artificial heart (TAH) use as a bridge to cardiac retransplantation is high-risk. Sensitization increases poor outcomes in these complex patients.
Area of Science:
- Cardiology
- Transplantation Medicine
- Mechanical Circulatory Support
Background:
- Mechanical circulatory support (MCS) is utilized as a bridge to cardiac retransplantation for graft failure.
- Limited data exists on the total artificial heart (TAH) specifically as a bridge to retransplantation.
Observation:
- This study reports on the institutional experience with three patients receiving a TAH as a bridge to cardiac retransplantation.
- One patient survived the retransplantation procedure.
Findings:
- The use of TAH as a bridge to cardiac retransplantation is associated with significant risks.
- Patient sensitization emerged as a critical factor correlating with adverse outcomes post-TAH and retransplantation.
Implications:
- Cardiac retransplantation candidates requiring TAH support face a high-risk scenario.
- Addressing pre-existing sensitization is crucial for improving outcomes in patients undergoing TAH bridging to retransplantation.
