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Updated: Nov 16, 2025

Generation of Natural Killer Cells from Human Expanded Potential Stem Cells
Published on: January 13, 2023
SIV-induced terminally differentiated adaptive NK cells in lymph nodes associated with enhanced MHC-E restricted
Nicolas Huot1, Philippe Rascle1,2, Caroline Petitdemange1
1Institut Pasteur, Unité HIV, Inflammation et Persistance, Paris, France.
Abstract:
Natural killer (NK) cells play a critical understudied role during HIV infection in tissues. In a natural host of SIV, the African green monkey (AGM), NK cells mediate a strong control of SIVagm infection in secondary lymphoid tissues. We demonstrate that SIVagm infection induces the expansion of terminally differentiated NKG2alow NK cells in secondary lymphoid organs displaying an adaptive transcriptional profile and increased MHC-E-restricted cytotoxicity in response to SIV Env peptides while expressing little IFN-γ. Such NK cell differentiation was lacking in SIVmac-infected macaques. Adaptive NK cells displayed no increased NKG2C expression. This study reveals a previously unknown profile of NK cell adaptation to a viral infection, thus accelerating strategies toward NK-cell directed therapies and viral control in tissues.
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