Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Photoreceptors and Visual Pathways01:22

Photoreceptors and Visual Pathways

7.9K
At the molecular level, visual signals trigger transformations in photopigment molecules, resulting in changes in the photoreceptor cell's membrane potential. The photon's energy level is denoted by its wavelength, with each specific wavelength of visible light associated with a distinct color. The spectral range of visible light, classified as electromagnetic radiation, spans from 380 to 720 nm. Electromagnetic radiation wavelengths exceeding 720 nm fall under the infrared category,...
7.9K
Photoreceptors and Plant Responses to Light02:00

Photoreceptors and Plant Responses to Light

27.7K
Light plays a significant role in regulating the growth and development of plants. In addition to providing energy for photosynthesis, light provides other important cues to regulate a range of developmental and physiological responses in plants.
27.7K
The Retina01:32

The Retina

73.3K
The retina is a layer of nervous tissue at the back of the eye that transduces light into neural signals. This process, called phototransduction, is carried out by rod and cone photoreceptor cells in the back of the retina.
73.3K
Channel Rhodopsins01:11

Channel Rhodopsins

2.9K
Most organisms use photoreceptors to sense and respond to light. Examples of photoreceptors include bacteriorhodopsins and bacteriophytochromes in some bacteria, phytochromes in plants, and rhodopsins in the photoreceptor cells of the vertebral retina. The light-sensitive property of these receptors is because of the bound chromophores, such as bilin in the phytochromes and retinal in the rhodopsins.
Rhodopsins belong to the family of cell surface proteins called G-protein coupled receptors,...
2.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Redox imbalance dictates dependence on GOT1 versus GOT2 for rod photoreceptor health during aging and stress.

Redox biology·2026
Same author

Comparative Cost Analysis of Pediatric and Adult Retinal Detachment Repairs Using Time-Driven Activity-Based Costing.

Journal of vitreoretinal diseases·2026
Same author

Redox imbalance dictates dependence on GOT1 versus GOT2 for rod photoreceptor health during aging and stress.

bioRxiv : the preprint server for biology·2026
Same author

Emerging solutions for neovascular age-related macular degeneration.

Current opinion in ophthalmology·2026
Same author

Acute and Substantial Vision Loss After Pembrolizumab Immunotherapy for Bladder Cancer.

JAMA ophthalmology·2025
Same author

Addressing Challenges in Developing Treatments for Inherited Retinal Diseases: Recommendations From the Third Monaciano Symposium.

Translational vision science & technology·2025

Related Experiment Video

Updated: Nov 16, 2025

Measurement of Energy Metabolism in Explanted Retinal Tissue Using Extracellular Flux Analysis
10:19

Measurement of Energy Metabolism in Explanted Retinal Tissue Using Extracellular Flux Analysis

Published on: January 7, 2019

9.7K

Photoreceptor metabolic reprogramming: current understanding and therapeutic implications.

Warren W Pan1, Thomas J Wubben2, Cagri G Besirli3

  • 1Department of Ophthalmology and Visual Sciences, Kellogg Eye Center, University of Michigan, Ann Arbor, MI, USA.

Communications Biology
|February 25, 2021
PubMed
Summary

Photoreceptor (PR) metabolism is crucial for vision and its disruption contributes to blindness in retinal diseases. Understanding these metabolic pathways may reveal new targets for therapies to prevent vision loss.

More Related Videos

Real-Time Analysis of Bioenergetics in Primary Human Retinal Pigment Epithelial Cells Using High-Resolution Respirometry
09:16

Real-Time Analysis of Bioenergetics in Primary Human Retinal Pigment Epithelial Cells Using High-Resolution Respirometry

Published on: February 3, 2023

2.8K
Author Spotlight: Extended Oxygen Consumption Measurement in Retinal Pigment Epithelium Using Resipher
08:09

Author Spotlight: Extended Oxygen Consumption Measurement in Retinal Pigment Epithelium Using Resipher

Published on: August 16, 2024

5.3K

Related Experiment Videos

Last Updated: Nov 16, 2025

Measurement of Energy Metabolism in Explanted Retinal Tissue Using Extracellular Flux Analysis
10:19

Measurement of Energy Metabolism in Explanted Retinal Tissue Using Extracellular Flux Analysis

Published on: January 7, 2019

9.7K
Real-Time Analysis of Bioenergetics in Primary Human Retinal Pigment Epithelial Cells Using High-Resolution Respirometry
09:16

Real-Time Analysis of Bioenergetics in Primary Human Retinal Pigment Epithelial Cells Using High-Resolution Respirometry

Published on: February 3, 2023

2.8K
Author Spotlight: Extended Oxygen Consumption Measurement in Retinal Pigment Epithelium Using Resipher
08:09

Author Spotlight: Extended Oxygen Consumption Measurement in Retinal Pigment Epithelium Using Resipher

Published on: August 16, 2024

5.3K

Area of Science:

  • Ophthalmology
  • Neuroscience
  • Cell Biology

Background:

  • Retinal disorders cause progressive vision loss primarily through photoreceptor (PR) death.
  • Current treatments for preventing PR loss are limited, highlighting an unmet clinical need.
  • PRs have high metabolic demands, and altered cell metabolism is implicated in PR death.

Purpose of the Study:

  • To review recent advances in understanding photoreceptor metabolism.
  • To explore the critical role of PR metabolism in redox balance and the outer retinal ecosystem.
  • To identify potential therapeutic targets for neuroprotection in retinal diseases.

Main Methods:

  • Literature review of recent studies on photoreceptor metabolism.
  • Analysis of the interplay between metabolism, redox balance, and retinal disease.
  • Synthesis of current knowledge on metabolic and redox pathways in PR health.

Main Results:

  • Photoreceptor metabolism is fundamental to maintaining retinal function and integrity.
  • Disruptions in nutrient availability and metabolic regulation are linked to PR death.
  • Metabolic processes are critical for maintaining the outer retinal metabolic ecosystem and redox balance.

Conclusions:

  • Understanding PR metabolism is essential for developing novel neuroprotective strategies.
  • Targeting metabolic and redox pathways offers a promising avenue for preventing blindness.
  • Further research into retinal cell metabolism is a priority for treating diverse retinal disorders.