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Updated: Nov 16, 2025
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Detection of Neuritic Plaques in Alzheimer's Disease Mouse Model
Published on: July 26, 2011
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Necrotic plaques in an elderly male.
Bindi Gaglani1, Ian Logan1, Faris Kubba1
1Department of Dermatology, Ealing Hospital, Southall, UB1 3HW, UK.
JRSM Open
|February 25, 2021
Summary
Giant reactive perforating collagenosis is a rare skin condition where collagen and elastin extrude through the epidermis. This case highlights an unusual giant form in an elderly diabetic patient.
Area of Science:
- Dermatology
- Pathology
Background:
- Reactive perforating collagenosis (RPC) is a rare genodermatosis.
- It involves transepithelial elimination of dermal components like collagen and elastin.
- RPC is often associated with underlying systemic diseases, including diabetes mellitus and renal disease.
Observation:
- A case of an 87-year-old male with diabetes mellitus is presented.
- The patient exhibited an unusually large or 'giant' form of reactive perforating collagenosis.
- This presentation is rare, especially in this age group.
Findings:
- The case demonstrates a giant variant of reactive perforating collagenosis.
- Histopathological examination would reveal characteristic transepithelial elimination of collagen and elastin.
- The association with diabetes mellitus is consistent with known comorbidities.
Implications:
- This case expands the spectrum of clinical presentations for reactive perforating collagenosis.
- It underscores the importance of considering RPC in diabetic patients with unusual skin lesions.
- Further research into the pathogenesis and management of giant RPC variants is warranted.
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