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Predictive Factors for Positive Surgical Margins in Patients With Prostate Cancer After Radical Prostatectomy: A
Lijin Zhang1, Hu Zhao1, Bin Wu1
1Department of Urology, Affiliated Jiang-yin Hospital of the Southeast University Medical College, Jiang-yin, China.
Frontiers in Oncology
|February 25, 2021
Summary
Positive surgical margins in prostate cancer are predicted by higher PSA, Gleason scores, advanced stage, positive lymph nodes, extraprostatic extension, and seminal vesicle invasion. These factors aid in risk stratification for personalized treatment.
Area of Science:
- Urology
- Oncology
- Surgical Pathology
Background:
- Positive surgical margins (PSMs) in prostate cancer (PCa) impact oncologic outcomes.
- Identifying predictors of PSMs after radical prostatectomy (RP) is crucial for patient management.
Approach:
- A meta-analysis was conducted on 27 studies involving 50,014 PCa patients.
- Risk factors for PSMs following RP were identified and pooled estimates calculated.
Key Points:
- Preoperative PSA, biopsy and pathological Gleason Scores, pathological stage, positive lymph nodes, extraprostatic extension, and seminal vesicle invasion significantly predict PSMs.
- Age, BMI, prostate volume, and nerve-sparing status did not show a significant association with PSMs.
Conclusions:
- Several clinical and pathological factors independently predict PSMs after RP.
- These findings support improved risk stratification and individualized therapy for PCa patients.
