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Pan-vasculitis and fulminant hepatitis following routine vaccination at the age of 4 months

Mohammad Hosny Awad1, Amany El-Hawary1, Gehan Sawah1

  • 1Department of Pediatrics, Faculty of Medicine, University of Mansoura, Mansoura, Egypt.

Clinical and Experimental Vaccine Research
|February 25, 2021
PubMed

Insights

Vaccine side effects can occur, including rare cases of vasculitis. This report details a severe case of hepatitis, pan vasculitis, and aneurysms in an infant after routine immunization.

Area of Science:

  • Pediatrics
  • Immunology
  • Cardiovascular Medicine

Background:

  • Vaccines are crucial for public health, but adverse events, though rare, require thorough investigation.
  • Vasculitis, inflammation of blood vessels, can manifest in various ways following vaccination.

Observation:

  • A 4-month-old infant developed fulminant hepatitis, widespread vasculitis, and multiple aneurysms post-routine immunization.
  • Diagnosis was confirmed using echocardiography and computed tomography angiogram.

Findings:

  • The infant's presentation was an unusual and severe manifestation of post-vaccination vasculitis.
  • Echocardiography and CT angiography were vital in diagnosing the extent of the vascular damage.

Implications:

  • Highlights the importance of recognizing diverse and severe vaccine adverse events.
  • Emphasizes the need for prompt diagnosis and treatment with therapies like intravenous immunoglobulins and corticosteroids.

Keywords:
ImmunizationVaccineVasculitis

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