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Updated: Nov 16, 2025
Shotgun Lipidomics of Rodent Tissues
Published on: November 18, 2022
Comparison of the effectiveness of variable selection method for creating a diagnostic panel of biomarkers for mass
Alisa O Tokareva1,2, Vitaliy V Chagovets3, Alexey S Kononikhin4
1Moscow Institute of Physics and Technology, Moscow, Russia.
Abstract:
Hundreds of compounds are detected during untargeted lipidomics analysis. The potential efficacy of lipids as disease markers makes it important to select the species with the most discriminative potential. Datasets based on a selected class of lipids allow the development of a high-quality diagnostic model using orthogonal projection on latent structure. The combination of selection of lipids by variable importance in projection and by Akaike information criteria makes it possible to build a reliable diagnostic model based on logistic regression.
