Complete blood cell count measures in retinal artey occlusions

Area of Science:

• Ophthalmology
• Hematology
• Internal Medicine

Background:

• Retinal artery occlusion (RAO) is a serious condition affecting vision.
• The role of routine blood count parameters in RAO pathogenesis is not fully understood.

Purpose of the Study:

• To investigate the association between complete blood cell count (CBC) indices and the occurrence of RAO.
• To evaluate specific CBC-derived ratios and indices as potential indicators for RAO.

Main Methods:

• A case-control study was conducted with 73 RAO patients and 73 matched controls.
• Complete blood cell counts (CBCs), including mean platelet volume (MPV) and red cell distribution width (RDW), were analyzed.
• Neutrophil/lymphocyte ratio (NLR), derived NLR (dNLR), and platelet/lymphocyte ratio (PLR) were calculated.

Main Results:

• RAO patients exhibited significantly higher levels of neutrophils, RDW, NLR, and dNLR compared to controls.
• No significant differences were observed in white blood cells, lymphocytes, platelet count, MPV, or PLR between groups.
• Multivariate analysis confirmed that increased RDW, NLR, and dNLR are significantly correlated with RAO occurrence.

Conclusions:

• RDW, NLR, and dNLR may be implicated in the pathogenesis of RAO.
• These CBC-derived indices show potential as predictive biomarkers for RAO.
• Further cohort studies are recommended to validate RDW, NLR, and dNLR as reliable RAO biomarkers.