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The association between statins exposure and peripheral neuropathy risk: A meta-analysis
Miao Wang1, Muqin Li1, Ying Xie1
1Department of Endocrinology, Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.
Journal of Clinical Pharmacy and Therapeutics
|February 25, 2021
Summary
This meta-analysis found no significant link between statin use and peripheral neuropathy (PN). While statins are crucial for cardiovascular health, this review of observational studies indicates they do not increase the risk of developing PN.
Area of Science:
- Cardiology
- Neurology
- Pharmacology
Background:
- Statins are essential lipid-lowering drugs for cardiovascular disease management.
- Peripheral neuropathy (PN) has been anecdotally linked to statin use, prompting investigation.
- Limited high-quality evidence exists on the statin-PN relationship.
Purpose of the Study:
- To systematically review and meta-analyze observational studies on the association between statin exposure and peripheral neuropathy risk.
Main Methods:
- Searched PubMed, Embase, Cochrane Library, and Web of Science for relevant studies up to December 3, 2020.
- Included randomized controlled trials and cohort studies; excluded reviews and studies lacking PN data.
- Utilized Newcastle-Ottawa Scale for quality assessment and meta-analysis for risk estimation, including subgroup analyses.
Main Results:
- Analyzed 9 independent studies involving 150,556 patients.
- Found a non-significant increase in PN with statin exposure (RR 1.26, 95% CI 0.92-1.74).
- Concluded no statistically significant association between statins and peripheral neuropathy risk.
Conclusions:
- Statin exposure does not appear to influence the risk of developing peripheral neuropathy.
- The current evidence quality is low, but findings offer preliminary insights for clinicians.
- Further research may be needed to definitively establish or refute this association.
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