Related Experiment Video
Updated: Nov 16, 2025
09:21
Author Spotlight: Generating Neuronal Phenotypic Profiles - A Protocol to Culture and Image Human Midbrain Dopaminergic Neurons
Published on: July 7, 2023
1.8K
Open science takes on Parkinson's disease
Ekemini Au Riley1, Randy Schekman1,2
1Aligning Science Across Parkinson's (ASAP), Chevy Chase, United States.
Elife
|February 25, 2021
Summary
The Aligning Science Across Parkinson's (ASAP) initiative enhances Parkinson's disease research through collaboration. ASAP aims to deepen understanding of Parkinson's disease mechanisms for novel therapy development.
Area of Science:
- Neuroscience
- Genetics
- Molecular Biology
Background:
- Parkinson's disease (PD) pathogenesis remains incompletely understood.
- A need exists for collaborative, open-science approaches to PD research.
Purpose of the Study:
- To improve the understanding of the biological basis of Parkinson's disease onset and progression.
- To foster a collaborative research network focused on PD pathology and neural circuits.
Main Methods:
- Established a large research network of nearly 100 investigators.
- Initiated and contributed to large-scale genetics and patient cohort studies.
- Emphasized open science principles and interdisciplinary collaboration.
Main Results:
- Assembled a significant research network dedicated to Parkinson's disease.
- Contributed to substantial genetics and patient cohort data initiatives.
- Network expansion planned to include neural circuit research.
Conclusions:
- The ASAP initiative is advancing Parkinson's disease research through a collaborative, multi-faceted approach.
- Enhanced understanding of molecular mechanisms is expected to drive novel therapeutic strategies for Parkinson's disease.
Related Concept Videos
01:15Parkinson's Disease: Overview
1.2K
Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...
1.2K
01:24Parkinson's Disease: Treatment
743
Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
743
01:21EPS and iPS Cells in Disease Research
3.1K
Embryonic and induced pluripotent stem cells are excellent models for disease research because of their ability to self-renew and differentiate into most cell types. Somatic cells from a patient are isolated and reprogrammed into induced pluripotent stem cells or iPSCs. These iPSCs are later differentiated into the desired cell type, which mirrors the diseased cell of the patient. In this way, disease models have been created for investigating diseases such as Down syndrome, type I diabetes,...
3.1K
01:37Neural Regulation
41.6K
Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
41.6K