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Isothiazolinones Common in Children's Toy Slime.

Keegan O'Hern, Shu T Liang, Ella Dendooven

¹Department of Dermatology, Dartmouth-Hitchcock Medical Center, Lebanon, NH.

Dermatitis : Contact, Atopic, Occupational, Drug

|February 25, 2021

Summary

Isothiazolinones, common preservatives, were found in many commercial slime products. Testing methods like the colorimetric spot test can be unreliable for detecting these chemicals in toys.

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Area of Science:

Dermatology
Toxicology
Consumer Product Safety

Background:

Contact dermatitis is frequently linked to homemade slime, with isothiazolinones suspected as the sensitizer.
Limited data exists on isothiazolinone presence in commercial slime products.

Purpose of the Study:

Review literature on "slime dermatitis."
Assess for isothiazolinones in commercial slimes and homemade slime components.

Main Methods:

Colorimetric spot test used on 38 commercial slimes, 1 homemade slime, and 4 components.
High-performance liquid chromatography with UV detection performed on 8 commercial slimes.

Main Results:

Spot test indicated isothiazolinones in 71% of commercial slimes.
HPLC-UV analysis revealed false-positives/negatives, correctly identifying isothiazolinones in only 50% of tested samples.

Conclusions:

First study to detect isothiazolinones in commercial slime toys.
Colorimetric spot test has limited utility as a specific and sensitive assay for methylisothiazolinone detection.