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Updated: Nov 16, 2025

Murine Hind Limb Long Bone Dissection and Bone Marrow Isolation
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Metabolic bone disorders after gastrectomy: inevitable or preventable?

Yasushi Rino1, Toru Aoyama2, Yosuke Atsumi2

  • 1Department of Surgery, School of Medicine, Yokohama City University, 3-9, Fukuura, Kanazawa-ku, Yokohama, 236-0004, Japan. rino@yokohama-cu.ac.jp.

Surgery Today
|February 25, 2021
PubMed
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Gastric cancer surgery can lead to metabolic bone disorders like osteoporosis due to reduced nutrient absorption. Bone mineral density decreases post-surgery but may stabilize over time, with potential benefits from alendronate therapy.

Keywords:
GastrectomyMetabolic bone disordersVitamin D

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Area of Science:

  • Gastroenterology
  • Endocrinology
  • Orthopedics

Background:

  • Metabolic bone disorders are suspected complications following gastrectomy for gastric cancer.
  • Limited detailed investigations exist on post-gastrectomy bone health.
  • Reduced nutrient intake, malabsorption, and steatorrhea are potential contributing factors.

Purpose of the Study:

  • To review and synthesize findings on metabolic bone disorders after gastrectomy for gastric cancer.
  • To analyze changes in bone mineral density (BMD) and vitamin D levels post-surgery.
  • To explore potential therapeutic interventions for post-gastrectomy bone complications.

Main Methods:

  • Review of a recent prospective study and existing literature.
  • Analysis of bone mineral density (BMD) changes over time post-gastrectomy.
  • Monitoring of 1,25(OH)2 vitamin D3 levels in patients.

Main Results:

  • Bone mineral density (BMD) significantly decreased within 12 months post-gastrectomy in both genders.
  • No significant gender-related difference was observed in the rate of BMD change.
  • BMD stabilized more than 1 year after surgery, with normal 1,25(OH)2 vitamin D3 levels maintained despite altered precursor availability.

Conclusions:

  • Gastrectomy for gastric cancer is associated with significant bone mineral density reduction.
  • While BMD may stabilize post-surgery, fracture incidence remains a concern.
  • Alendronate therapy shows potential for preventing post-gastrectomy bone disorders, but optimal strategies require further delineation.