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Cannabis and Migraine: It's Complicated
Laszlo L Mechtler1, Fran M Gengo2, Vincent H Bargnes3
1Dent Neurologic Institute, 3980 Sheridan Drive, Suite 600, Amherst, NY, 14226, USA. lmechtler@dentinstitute.com.
Current Pain and Headache Reports
|February 25, 2021
Summary
Medical cannabis may improve migraine symptoms and reduce medication use, particularly opioids. While side effects are generally mild, more research is needed for specific dosing guidelines for cannabis in migraine treatment.
Area of Science:
- Neurology
- Pharmacology
Background:
- The legalization of medical cannabis in the USA has increased interest in its use for migraine treatment.
- Understanding cannabinoid mechanisms and available research is vital for healthcare providers.
Purpose of the Study:
- To review existing research on cannabis for migraine.
- To offer clinical recommendations for cannabis use in migraine management.
Main Methods:
- Literature review of studies on cannabis and migraine.
- Analysis of clinical management experiences.
Main Results:
- Patients report improved migraine profiles and comorbidities with medical cannabis use.
- A reduction in prescription medications, especially opioids, is frequently observed.
- Observed effects appear mediated by tetrahydrocannabinol (THC) and cannabidiol (CBD), though specific dosage data is limited. Mild side effects are common.
Conclusions:
- Cannabis shows potential in managing migraine and associated conditions.
- Further research is required to establish optimal dosing and efficacy.
- Clinical practice should consider patient-reported outcomes and potential benefits alongside risks.
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