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Detection of Nasal Solitary Extramedullary Plasmacytoma on 18F-FDG PET/CT Imaging
Abstract:
A 46-year-old man presented with a 3-month history of epistaxis. CT and MRI scan showed a soft tissue mass in the left nasal cavity. An excisional biopsy of the mass revealed extramedullary plasmacytoma. 18F-FDG PET/CT showed intense activity in the region of the left nasal cavity but no other FDG-avid lesions. Additional workups did not reveal any evidence of systematic disease. Based on these findings, the patient was diagnosed as having solitary nasal extramedullary plasmacytoma. He received the local radiation therapy. During the 3-month follow-up, his symptom was relieved.
Insights
A solitary nasal extramedullary plasmacytoma, a rare cancer, was diagnosed in a man with recurrent epistaxis. Treatment with radiation therapy provided symptom relief, highlighting effective localized management for this uncommon condition.
Area of Science:
- Oncology
- Radiology
- Pathology
Background:
- Extramedullary plasmacytoma (EMP) is a rare plasma cell neoplasm occurring outside the bone marrow.
- Nasal cavity involvement is uncommon, presenting diagnostic challenges.
- Early diagnosis and treatment are crucial for patient outcomes.
Observation:
- A 46-year-old man presented with a 3-month history of epistaxis.
- Imaging (CT and MRI) revealed a soft tissue mass in the left nasal cavity.
- Excisional biopsy confirmed extramedullary plasmacytoma.
Findings:
- 18F-FDG PET/CT demonstrated intense activity in the nasal mass, with no evidence of systemic disease.
- The patient was diagnosed with solitary nasal extramedullary plasmacytoma.
- Workup excluded multiple myeloma or other systemic plasma cell disorders.
Implications:
- Solitary nasal extramedullary plasmacytoma requires a high index of suspicion for accurate diagnosis.
- Localized radiation therapy can be an effective treatment modality.
- This case underscores the importance of thorough workup to rule out systemic disease.
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