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Related Experiment Videos

Intravascular contrast media: effect of dose on renal function.

D L Miller1, R Chang, W T Wells

  • 1Diagnostic Radiology Department, Clinical Center, National Institutes of Health, Bethesda, MD 20892.

Radiology
|June 1, 1988
PubMed
Summary

This study found no consistent clinical effect on renal function from increasing doses of contrast material in adequately hydrated, low-risk patients. Contrast material dose did not significantly alter kidney function in the examined patient group.

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Area of Science:

  • Radiology
  • Nephrology

Background:

  • Contrast material administration is common in medical imaging.
  • Assessing the impact of contrast material dose on renal function is crucial for patient safety.

Purpose of the Study:

  • To prospectively evaluate the effect of varying contrast material doses on clinically evident changes in renal function.
  • To determine if contrast material dose impacts renal function in adequately hydrated, low-risk patients.

Main Methods:

  • Prospective study of 200 examinations involving intravenous or intraarterial contrast material.
  • Measurement of blood urea nitrogen and serum creatinine before and after contrast administration.
  • Analysis of data considering ionic and nonionic contrast agents and total dose administered.

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Main Results:

  • No consistent clinical effect on renal function was observed with increasing contrast material dose.
  • This finding held true regardless of whether ionic or nonionic agents were used.
  • No relationship was found between total dose and patient age or dose adjustments for pre-existing renal impairment.

Conclusions:

  • In adequately hydrated, low-risk patients with normal initial renal function, increasing contrast material dose within the studied range does not appear to cause consistent clinical changes in renal function.
  • The type of contrast agent (ionic vs. nonionic) did not alter this outcome.