Related Experiment Video

Updated: Nov 16, 2025

A Volumetric Method for Quantification of Cerebral Vasospasm in a Murine Model of Subarachnoid Hemorrhage
08:12

A Volumetric Method for Quantification of Cerebral Vasospasm in a Murine Model of Subarachnoid Hemorrhage

Published on: July 28, 2018

8.3K

Role of Cilostazol in Prevention of Vasospasm After Aneurysmal Subarachnoid Hemorrhage-A Systematic Review,

Sandeep Bohara1, Kanwaljeet Garg1, Preet Mohinder Singh Rajpal2

  • 1Department of Neurosurgery, All India Institute of Medical Sciences, New Delhi, India.

World Neurosurgery
|February 25, 2021
PubMed

Insights

Cilostazol effectively reduces symptomatic vasospasm, new-onset infarcts, and angiographic vasospasm following aneurysmal subarachnoid hemorrhage (aSAH). This meta-analysis confirms its benefit in preventing poor outcomes after aSAH.

Area of Science:

  • Neurology
  • Pharmacology

Background:

  • Cerebral vasospasm is a frequent complication after aneurysmal subarachnoid hemorrhage (aSAH), leading to delayed cerebral ischemia.
  • Various pharmacological agents have been investigated to prevent or treat cerebral vasospasm and its consequences.

Purpose of the Study:

  • To evaluate the efficacy of cilostazol, a phosphodiesterase 3 inhibitor, in mitigating cerebral vasospasm and delayed cerebral ischemia post-aSAH.
  • To perform a meta-analysis and trial sequential analysis to ascertain the effect of cilostazol on cerebral vasospasm after aSAH.

Main Methods:

  • A systematic literature search identified eligible randomized controlled trials.
  • Meta-analysis and trial sequential analysis were conducted on the selected studies.

Main Results:

  • Four randomized controlled trials involving 454 articles were analyzed.
  • Cilostazol significantly reduced symptomatic vasospasm (OR 0.35), new-onset infarct (OR 0.38), and angiographic vasospasm (OR 0.49).
  • The drug also decreased the risk of unfavorable outcomes (RR 0.52).

Conclusions:

  • Cilostazol administration post-aSAH is associated with decreased prevalence of symptomatic vasospasm, new-onset infarct, and angiographic vasospasm.
  • Trial sequential analysis confirmed the robustness of these findings.
  • Further multi-geographic studies are recommended to generalize these results.
Abstract

Keywords:
AneurysmCilostazolDelayed cerebral ischemiaMortalitySubarachnoid hemorrhageVasospasm

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