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Inhibition of glyoxalase I by various clinically used anticancer drugs
J L Kraus1, P Pernice, C Ponce
1Laboratoire de Chimie Biomoléculaire, Faculté des Sciences de Luminy, Marseille, France.
Research Communications in Chemical Pathology and Pharmacology
|March 1, 1988
Abstract:
The antiglyoxalase activity of eight well-known anticancer drugs has been evaluated, their I50 values were determinated and compared to those of standard inhibitors S-octylglutathione and squaric acid. Among them methotrexate was found to be as potent as S-octylglutathione.