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Updated: Nov 16, 2025

Author Spotlight: Investigating the Key Factors of Obliterative Bronchiolitis After Lung Transplantation
Published on: November 10, 2023
Bronchiectasis severity correlates with outcome in patients with primary antibody deficiency
Jimstan Periselneris1, Silke Schelenz2, Michael Loebinger3
1Respiratory Medicine, King's College Hospital NHS Foundation Trust, London, UK jperiselneris@nhs.net.
Abstract:
Bronchiectasis is a well-recognised complication of primary antibody deficiency (PAD) syndromes. Previous data suggest that mortality in common variable immune deficiency (CVID) is not associated with isolated bronchiectasis. A retrospective analysis of patients with CVID and specific antibody deficiency in two tertiary referral centres with lung disease was conducted. Severity of bronchiectasis at presentation was associated with mortality. Lower FEV1, colonisation with Pseudomonas aeruginosa and a diagnosis of COPD were also associated with mortality. Bronchiectasis is an important driver of mortality in patients with PAD syndromes.
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