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The mitral regurgitation effects of cardiac structure and function in left ventricular noncompaction

Qing Zou1,2, Rong Xu1, Xiao Li3

  • 1Department of Radiology, Key Laboratory of Birth Defects and Related Diseases of Women and Children of Ministry of Education, West China Second University Hospital, Sichuan University, 20# Section 3 South Renmin Road, Chengdu, 610041, China.

Scientific Reports
|February 26, 2021
PubMed

Insights

Mitral regurgitation (MR) is common in left ventricular noncompaction (LVNC) patients, worsening cardiac function and structure. These findings highlight the impact of MR on LVNC progression and heart failure symptoms.

Area of Science:

  • Cardiology
  • Cardiovascular Imaging
  • Cardiac Physiology

Background:

  • Left ventricular noncompaction (LVNC) is a rare congenital cardiomyopathy.
  • The impact of mitral regurgitation (MR) on cardiac structure and function in LVNC patients requires further elucidation.

Purpose of the Study:

  • To evaluate the effects of mitral regurgitation (MR) on cardiac structure and function in patients with left ventricular noncompaction (LVNC).

Main Methods:

  • Retrospective analysis of clinical and cardiovascular magnetic resonance (CMR) data from 182 LVNC patients.
  • Comparison of left ventricular geometry and function between LVNC patients with and without MR.

Main Results:

  • MR was present in 48.2% of LVNC patients and associated with worse NYHA class and higher arrhythmia incidence.
  • LVNC patients with MR exhibited reduced 2D sphericity, longitudinal shortening, and global/segmental peak longitudinal strain (PLS).
  • End-diastolic volume, end-systolic volume, and global PLS correlated with MR and NYHA class.

Conclusions:

  • Mitral regurgitation is a frequent comorbidity in LVNC patients.
  • The presence of MR significantly exacerbates cardiac morphological and functional impairment in LVNC.
  • Hypertrabeculation is not a primary driver of cardiac dysfunction in advanced heart failure stages of LVNC.

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