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Mouse Models Of Helicobacter Infection And Gastric Pathologies
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Mouse Models Of Helicobacter Infection And Gastric Pathologies

Published on: October 18, 2018

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Helicobacter and the Potential Role in Neurological Disorders: There Is More Than Helicobacter pylori

Nina Gorlé1,2, Eva Bauwens3, Freddy Haesebrouck3

  • 1VIB Center for Inflammation Research, Ghent, Belgium.

Frontiers in Immunology
|February 26, 2021
PubMed

Insights

Gastric Helicobacter suis infections may impact brain health via the microbiome-gut-brain axis. This study explores the link between H. suis and neurological disorders, particularly Parkinson

Area of Science:

  • Microbiome-gut-brain axis
  • Neuroscience
  • Microbiology

Background:

  • The human gut hosts trillions of microbes crucial for health, with dysbiosis linked to diseases.
  • Emerging evidence connects gut microbiota alterations to neurological disorders.
  • The microbiome-gut-brain axis describes bidirectional communication between gut microbes and the brain.

Purpose of the Study:

  • To investigate the potential role of Helicobacter suis in neurological disorders.
  • To explore the mechanisms by which H. suis may influence brain function via the microbiome-gut-brain axis.

Main Methods:

  • Review of recent studies on H. suis prevalence in Parkinson's disease patients.
  • Discussion of a prior study demonstrating H. suis infection effects on mouse brain homeostasis.
  • Analysis of potential communication routes within the microbiome-gut-brain axis.

Main Results:

  • A high prevalence of H. suis was recently reported in Parkinson's disease patients.
  • Gastric H. suis infection was shown to affect brain homeostasis in a mouse model.
  • The potential impact of H. suis on neurological disorders via the microbiome-gut-brain axis is highlighted.

Conclusions:

  • H. suis is a potential factor in the development or progression of neurological disorders.
  • Further research is warranted to elucidate the specific mechanisms of H. suis in brain health.
  • Understanding H. suis's role in the microbiome-gut-brain axis is crucial for neurological disease insights.
Keywords:
Helicobacter pyloriHelicobacter suisgut microbiotamicrobiome–gut–brain axisneurological disorders

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