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Impedance-based Real-time Measurement of Cancer Cell Migration and Invasion
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Complex roles of discoidin domain receptor tyrosine kinases in cancer

V Mehta1, H Chander2,3, A Munshi2

  • 1Department of Human Genetics and Molecular Medicine, Central University of Punjab, Bathinda, 151001, India. vikrantmehta80@gmail.com.

Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico
|February 26, 2021
PubMed

Insights

Discoidin domain receptors (DDR1 and DDR2) are receptor tyrosine kinases involved in cell regulation. Their dual role in promoting and suppressing cancer progression makes them complex therapeutic targets.

Area of Science:

  • Molecular Biology
  • Cellular Biology
  • Oncology

Background:

  • Discoidin domain receptors (DDR1 and DDR2) are receptor tyrosine kinases.
  • They function as non-integrin collagen receptors.
  • Initially recognized for roles in embryonic development and homeostasis.

Purpose of the Study:

  • To review the multifaceted roles of DDR1 and DDR2 in cancer.
  • To elucidate their involvement in tumorigenesis and metastasis.
  • To highlight their potential as therapeutic targets.

Main Methods:

  • Literature review of studies on DDR1 and DDR2 in cancer.
  • Analysis of their functions in ECM remodeling, invasion, and drug resistance.
  • Examination of their roles in apoptosis and tumor suppression.

Main Results:

  • DDRs can promote tumor progression and metastasis by augmenting ECM remodeling and invasion.
  • Conversely, DDRs have been shown to induce apoptosis and suppress tumor growth in certain cancers.
  • The precise functions of DDRs in cancer are context-dependent and remain ill-defined.

Conclusions:

  • DDR1 and DDR2 exhibit complex, often opposing, roles in cancer development.
  • Their dual functions present challenges and opportunities for cancer therapy.
  • Further research is needed to fully understand and exploit DDRs as therapeutic targets.
Keywords:
Cancer cell signallingCollagenDiscoidin domain receptorInvasionMetastasisReceptor tyrosine kinase

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