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Serous fluid cytopathology: Past, present, and future
1Department of Pathology, University Hospitals Cleveland Medical Center/Case Western Reserve University, Cleveland, Ohio, USA.
Diagnostic Cytopathology
|February 26, 2021
Summary
Serous fluid analysis aids in diagnosing various diseases using microscopy and molecular tests. The International Reporting System for Serous Fluid Cytopathology (IRSSF) standardizes terminology and criteria for effusion diagnosis.
Area of Science:
- Cytopathology
- Oncology
- Molecular Diagnostics
Background:
- Serous fluids/effusions are crucial cytology samples reflecting diverse pathologies.
- Traditional analyses include microscopy, chemical assays, cell counts, and cultures.
- Emerging role of effusions as liquid biopsies for molecular testing.
Discussion:
- Effusions are increasingly utilized for thoranostic and prognostic marker identification.
- Molecular interrogation aids in selecting targeted therapies for various conditions.
- The International Reporting System for Serous Fluid Cytopathology (IRSSF) establishes standardized reporting.
Key Insights:
- IRSSF provides standardized terminology and well-defined diagnostic criteria for serous fluid analysis.
- The system facilitates consistent and reliable reporting of effusion cytology findings.
- Comprehensive review of effusion work-up progress and IRSSF contributions.
Outlook:
- Future directions in serous fluid analysis and the impact of standardized reporting.
- Integration of molecular profiling into routine effusion diagnostics.
- Advancements in thoranostic applications leveraging effusion-based liquid biopsies.
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