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Updated: Nov 16, 2025

Assessing Therapeutic Angiogenesis in a Murine Model of Hindlimb Ischemia
Published on: June 8, 2019
Repeat BTK revascularization: when, how and what are the results?
Sabine Steiner1, Andrej Schmidt2
1Division of Angiology, Department of Internal Medicine, Neurology and Dermatology, University Hospital Leipzig, Leipzig, Germany - Sabine.steiner@medizin.uni-leipzig.de.
Insights
Repeat below-the-knee (BTK) endovascular interventions are necessary due to high re-stenosis rates after initial procedures. This review examines the need, options, and outcomes for repeat BTK interventions in chronic limb-threatening ischemia patients.
Area of Science:
- Vascular Surgery
- Interventional Cardiology
- Endovascular Interventions
Background:
- Increasing prevalence of chronic limb-threatening ischemia (CLTI) due to aging populations and diabetes.
- Below-the-knee (BTK) lesions are common in CLTI, requiring complex revascularization.
- Advances in endovascular techniques and devices have improved short-term outcomes for BTK interventions.
Purpose of the Study:
- To summarize current knowledge on repeat BTK interventions for CLTI.
- To review the indications, available options, and outcomes of repeat BTK procedures.
- To present data on repeat interventions in complex peripheral arterial occlusive disease.
Main Methods:
- Limited literature review of MEDLINE, EMBASE, and conference proceedings.
- Keywords included "angioplasty," "endovascular intervention," "infrapopliteal," "tibial arteries," and "below the knee."
- Search focused on English-language publications from 2000 to 2020.
Main Results:
- High rates of re-stenosis and re-occlusion are observed after initial infrapopliteal interventions.
- These high rates limit the long-term success of primary procedures.
- Frequent repeat interventions are often necessary to maintain patency and limb salvage.
Conclusions:
- Repeat BTK interventions are crucial for managing CLTI patients with recurrent disease.
- Understanding the need, options, and outcomes of repeat procedures is essential for optimizing patient care.
- Further research and data presentation are needed to refine strategies for repeat BTK interventions.
Introduction:
Owing to the ageing of the population and rising rates of diabetes, more patients suffering from chronic limb threatening ischemia (CLTI) need revascularization for often complex, multilevel peripheral arterial occlusive disease. Below the knee (BTK) lesions are common in CLTI and short-term outcomes of BTK endovascular revascularizations have improved substantially over the last decade as a consequence of improved techniques and dedicated low profile devices.
Evidence Acquisition:
The manuscript summarized the information identified through a limited literature review conducted on key resources including MEDLINE and EMBASE databases as well as conference proceedings. The keywords were "angioplasty," "endovascular intervention," "infrapopliteal," "tibial arteries" and "below the knee." The search was limited to contemporary English-language documents published between 2000 and 2020.
Evidence Synthesis:
Rates of re-stenosis and re-occlusion are high after infrapopliteal interventions limiting long-term success and necessitating frequent repeat procedures.
Conclusions:
In this article we aimed to summarize current knowledge regarding the need, options and outcome of repeat BTK interventions through a limited literature review and presentation of own data.
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