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Related Experiment Videos

Protein C in acute stroke.

A D'Angelo1, G Landi, S Vigano'D'Angelo

  • 1Coagulation Service, Istituto Scientifico Ospedale S. Raffaele, Milano, Italy.

Stroke
|May 1, 1988
PubMed
Summary
This summary is machine-generated.

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Lower protein C levels in acute stroke patients correlate with higher mortality. Increased fibrinopeptide A suggests protein C activation contributes to stroke-related hemostatic changes, supporting trials for protein C supplementation in ischemic stroke.

Area of Science:

  • Biochemistry
  • Neurology
  • Hematology

Background:

  • Protein C is a crucial anticoagulant protein.
  • Hemostatic balance is often disrupted in acute ischemic stroke.

Purpose of the Study:

  • To investigate the role of protein C and fibrinopeptide A in acute hemispheric stroke.
  • To compare these markers between stroke patients and controls, and between stroke survivors and nonsurvivors.

Main Methods:

  • Plasma concentrations of protein C and fibrinopeptide A were measured in 37 acute stroke patients and age-matched controls.
  • Patients were categorized into survivors and nonsurvivors based on mortality within 15 days.

Main Results:

  • Nonsurvivors had significantly lower protein C concentrations than survivors and controls.

Related Experiment Videos

  • All stroke patients exhibited elevated fibrinopeptide A, with higher levels in nonsurvivors.
  • Protein C levels in survivors were slightly elevated compared to controls and normalized by 2 months post-stroke.

    • Conclusions:

    • Protein C plays a significant role in the hemostatic disturbances associated with acute ischemic stroke.
    • Lower protein C levels in nonsurvivors may result from increased thrombin-mediated activation.
    • These findings support further clinical trials on protein C supplementation for acute ischemic stroke treatment.