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The Effect of Aging on Tissues

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Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...

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Related Experiment Video

Updated: Nov 16, 2025

An in vivo Rodent Model of Contraction-induced Injury and Non-invasive Monitoring of Recovery

An in vivo Rodent Model of Contraction-induced Injury and Non-invasive Monitoring of Recovery

Published on: May 11, 2011

The AGE Reader: A non-invasive method to assess long-term tissue damage.

I M Atzeni¹, S C van de Zande¹, J Westra²

¹Dept. of Internal Medicine, Div. of Vascular Medicine, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

Methods (San Diego, Calif.)

|February 26, 2021

Summary

Advanced glycation endproducts (AGEs) are linked to various diseases. The AGE Reader non-invasively measures skin autofluorescence (SAF), but factors like melanin and lifestyle can affect results.

Keywords:

AGE Reader Advanced glycation endproducts Skin autofluorescence

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Published on: August 31, 2022

Area of Science:

Biochemistry
Dermatology
Gerontology

Background:

Advanced glycation endproducts (AGEs) are formed during non-enzymatic glycoxidative stress.
Elevated AGEs are associated with various acute and chronic diseases.
Invasive skin biopsies are typically required for AGE measurement.

Purpose of the Study:

To introduce the AGE Reader, a device for non-invasive skin autofluorescence (SAF) assessment.
To review the functionality of the AGE Reader.
To identify factors influencing SAF measurements.

Main Methods:

Non-invasive assessment of skin autofluorescence (SAF) using the AGE Reader.
Evaluation of endogenous factors (e.g., melanin) affecting SAF.
Analysis of exogenous factors (e.g., nutrition, skincare) impacting SAF.

Main Results:

SAF is a validated marker for oxidative stress-related disease processes.
SAF predicts cardiovascular events and mortality in various populations.
Reliability of SAF measurements can be limited by endogenous and exogenous factors.

Conclusions:

The AGE Reader offers a non-invasive method to assess AGE accumulation.
Understanding influencing factors is crucial for accurate individual SAF assessment.
Further research is needed to refine SAF measurement protocols.