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Studying Diabetes Through the Eyes of a Fish: Microdissection, Visualization, and Analysis of the Adult tgfli:EGFP Zebrafish Retinal Vasculature
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Double Diabetes: A Growing Problem Requiring Solutions.

Djordje S Popovic1,2, Nikolaos Papanas3

  • 1Clinic for Endocrinology, Diabetes and Metabolic Disorders, Clinical Center of Vojvodina, Novi Sad, SERBIA.

Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [And] German Diabetes Association
|February 26, 2021
PubMed
Summary
This summary is machine-generated.

Double diabetes, a subgroup of type 1 diabetes mellitus (T1DM) with insulin resistance (IR), presents a poorer metabolic phenotype. Early identification and T2DM therapies may mitigate associated risks and complications.

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Area of Science:

  • Endocrinology
  • Metabolic Diseases
  • Diabetes Research

Background:

  • Increasing prevalence of insulin resistance (IR) in type 1 diabetes mellitus (T1DM) patients.
  • Emergence of a distinct T1DM subgroup, 'double diabetes,' with potential for worse outcomes.
  • Current guidelines do not recognize this T1DM subgroup.

Purpose of the Study:

  • To highlight the significance of identifying double diabetes.
  • To emphasize the need for timely therapeutic interventions.
  • To reduce the risk of chronic complications and adverse metabolic traits in T1DM patients with IR.

Main Methods:

  • Review of proposed diagnostic criteria for double diabetes.
  • Discussion of potential diagnostic markers, including estimated glucose disposal rate.
  • Exploration of therapeutic strategies for double diabetes.

Main Results:

  • Double diabetes is estimated to affect up to half of T1DM patients.
  • Diagnostic criteria include family history of type 2 diabetes mellitus (T2DM), obesity/metabolic syndrome, and IR.
  • Estimated glucose disposal rate may be a reliable diagnostic marker.

Conclusions:

  • Double diabetes patients may benefit from T2DM agents like GLP-1 receptor agonists and SGLT-2 inhibitors.
  • Further long-term trials are needed to assess the benefits of these agents.
  • Timely identification and management are crucial for improving outcomes in this T1DM subgroup.