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SMYD3: a regulator of epigenetic and signaling pathways in cancer

Benjamin J Bernard1, Nupur Nigam1, Kyunghee Burkitt2

  • 1Thoracic and GI Malignancies Branch, Center for Cancer Research, National Cancer Institute, 41 Medlars Drive, Bethesda, MD, 20852, USA.

Clinical Epigenetics
|February 27, 2021
PubMed

Insights

SMYD3 is a chromatin modifier involved in cancer development. This review details its substrates and implications, exploring potential therapeutic inhibitors for cancer treatment.

Area of Science:

  • Oncology
  • Epigenetics
  • Molecular Biology

Background:

  • Chromatin modifiers regulate gene transcription through post-translational modifications.
  • SET and MYN-domain containing 3 (SMYD3) is an enzyme implicated in various cancers.
  • SMYD3's initial role was tri-methylation of Histone 3 Lysine 4 (H3K4), a transcription-promoting mark.

Purpose of the Study:

  • To review the basic characteristics of SMYD3, including protein structure and expression.
  • To discuss identified histone and non-histone substrates of SMYD3.
  • To highlight the prognostic and functional significance of SMYD3 in oncogenesis and explore therapeutic strategies.

Main Methods:

  • Literature review of existing research on SMYD3.
  • Analysis of studies detailing SMYD3's enzymatic activity and substrate interactions.
  • Synthesis of data on SMYD3's role in cancer progression and therapeutic targeting.

Main Results:

  • SMYD3 modifies various histone and non-histone proteins beyond H3K4.
  • SMYD3 plays a significant role in the development and progression of multiple cancer types.
  • Emerging research focuses on developing SMYD3 inhibitors for cancer therapy.

Conclusions:

  • SMYD3 is a critical regulator in cancer, acting on diverse substrates.
  • Understanding SMYD3's functions is key to developing novel cancer treatments.
  • Targeting SMYD3 presents a promising therapeutic avenue for oncological diseases.
Keywords:
Chromatin modifierHistone methylationNon-histone methylationSMYD3SMYD3 cancer implications

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