Related Experiment Video

Updated: Nov 16, 2025

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
04:44

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

20.5K

[Characteristics of cardiac involvement in eosinophilic granulomatosis with polyangiitis]

A Belhassen1, S Toujani1, A El Ouni1

  • 1Service de médecine interne, centre hospitalier universitaire Mongi-Slim, 2070 La Marsa, Tunisie.

Annales De Cardiologie Et D'Angeiologie
|February 27, 2021
PubMed

Insights

Cardiac involvement, including cardiomyopathy, frequently reveals eosinophilic granulomatosis with polyangiitis (EGPA), particularly in women. Late-onset asthma and hypereosinophilia are key diagnostic clues for this ANCA-negative vasculitis.

Area of Science:

  • Rheumatology
  • Cardiology
  • Internal Medicine

Background:

  • Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare systemic vasculitis.
  • Cardiac involvement is a significant cause of morbidity and mortality in EGPA.
  • Understanding the cardiac manifestations of EGPA is crucial for timely diagnosis and management.

Purpose of the Study:

  • To identify the specific characteristics of cardiac involvement in patients with EGPA.
  • To analyze the clinical presentation, diagnostic findings, and outcomes of cardiac manifestations in EGPA.

Main Methods:

  • Retrospective analysis of EGPA cases diagnosed between 2000 and 2019.
  • Inclusion criteria based on 1990 American College of Rheumatology and 2012 Chapel Hill Consensus criteria.
  • Evaluation of cardiac manifestations using clinical data and cardiac magnetic resonance imaging (MRI).

Main Results:

  • Eleven EGPA cases were included, with 64% female patients; cardiac damage revealed EGPA in 55% of cases.
  • Common cardiac manifestations included myocarditis, ischemic cardiomyopathy, cardiac tamponade, and intracardiac thrombus.
  • Cardiac MRI revealed subendocardial changes, impaired left ventricle function, and micro-infarctions; 83.3% of cases were ANCA-negative.

Conclusions:

  • Cardiomyopathy is a frequent and often presenting feature of EGPA.
  • Late-onset asthma and hypereosinophilia are important indicators for EGPA diagnosis.
  • Histological confirmation is recommended due to frequent ANCA negativity; the role of cardiac MRI requires further definition.
Abstract

Keywords:
Antibodies antineutrophil cytoplasmicAnticorps anti-cytoplasme des polynucléaires neutrophilesCardiac tamponadeCardiomyopathieCardiomyopathyDiagnostic imagingEosinophilic granulomatosis with polyangiitisGranulomatose éosinophilique avec polyangéiteImagerie diagnostiqueMyocarditeMyocarditisPericarditisPéricarditeTamponnade cardiaqueVasculariteVasculitis

More Related Videos

Author Spotlight: Investigating the Pathophysiology of Eosinophilic Esophagitis03:23

Author Spotlight: Investigating the Pathophysiology of Eosinophilic Esophagitis

Published on: May 10, 2024

1.1K
An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis06:35

An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis

Published on: February 8, 2019

7.4K

Related Concept Videos

Endocarditis II: Clinical Features of Infective Endocarditis01:25

Endocarditis II: Clinical Features of Infective Endocarditis

Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
143
Myocarditis II: Clinical Features and Diagnostic Tests01:27

Myocarditis II: Clinical Features and Diagnostic Tests

Myocarditis is an inflammation of the heart muscle. The symptoms vary widely, encompassing asymptomatic presentations to severe, acute manifestations.Clinical PresentationAsymptomatic cases: In some instances, myocarditis may be asymptomatic, with the infection resolving without intervention. These cases often go undetected unless discovered incidentally through diagnostic imaging or tests conducted for other reasons.General Early Symptoms: Early symptoms of myocarditis are non-specific and can...
96
Pericarditis II: Clinical Features and Diagnostic Tests01:19

Pericarditis II: Clinical Features and Diagnostic Tests

Pericarditis is distinguished by inflammation of the pericardium, the fibrous sac that encases the heart. It can be acute, lasting less than six weeks, or chronic, persisting for over three months. Understanding its clinical manifestations and diagnostic findings is crucial for timely and effective management.Clinical ManifestationsWhile pericarditis can be asymptomatic, it usually presents with characteristic symptoms such as:Chest Pain: The most characteristic symptom of pericarditis is chest...
141
Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
144
Myocarditis I: Introduction01:21

Myocarditis I: Introduction

Myocarditis is inflammation of the myocardium, which is the muscular layer of the heart.EtiologyMyocarditis has a diverse etiology, including a wide range of infectious and non-infectious causes:Infectious CausesViral: Common viruses include Coxsackie A and B, adenovirus, parvovirus B19, enteroviruses, and influenza A.Bacterial: Examples include infections caused by Streptococcus, Staphylococcus, and Mycoplasma species.Rickettsial: Infections like Rocky Mountain spotted fever can result in...
153
Rheumatic Heart Disease I: Introduction01:23

Rheumatic Heart Disease I: Introduction

Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
181