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Lawsonella clevelandensis: an emerging cause of vascular graft infection

Rommel Ramesh1,2, Mariam Assi2, Zerelda Esquer Garrigos2,3

  • 1Charles University Faculty of Medicine in Hradec Kralove, Hradec Kralove, Czech Republic.

BMJ Case Reports
|February 27, 2021
PubMed

Insights

Lawsonella clevelandensis, an emerging pathogen, can cause serious infections like vascular graft infections. Early identification via molecular methods and appropriate treatment are crucial for patient recovery.

Area of Science:

  • Medical Microbiology
  • Infectious Diseases
  • Clinical Diagnostics

Background:

  • Lawsonella clevelandensis is an emerging pathogen first identified in 2016.
  • It is a fastidious organism primarily detected using molecular diagnostic techniques.
  • Increasing use of broad-range PCR has led to more frequent reporting of L. clevelandensis.

Observation:

  • A case of a 65-year-old male patient with bilateral psoas abscesses is presented.
  • The abscesses were secondary to an infected aorto-bi-iliac vascular graft.
  • Lawsonella clevelandensis was identified as the causative agent using 16S rRNA/PCR sequencing.

Findings:

  • Successful treatment involved surgical resection and replacement of the infected graft.
  • The patient received 6 weeks of intravenous antibiotic therapy.
  • Chronic suppression with doxycycline and cefadroxil was administered post-initial treatment.

Implications:

  • This case highlights L. clevelandensis as a cause of vascular graft infections.
  • Molecular methods are essential for diagnosing infections by fastidious organisms like L. clevelandensis.
  • A combination of surgical intervention and tailored antibiotic therapy can lead to successful patient outcomes.
Keywords:
infectionsnosocomial infections

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