Related Experiment Video
Updated: Nov 16, 2025

Triplet Fusion Upconversion Nanocapsule Synthesis
Published on: September 7, 2022
Total Synthesis of Panaginsene
Vipin Kumar Singh1, Tushar Kanti Chakraborty1
1Department of Organic Chemistry, Indian Institute of Science, Bengaluru, 560012, India.
Abstract:
The total synthesis of panaginsene has been accomplished in 11 linear steps starting from methyl 3,3-dimethyl-5-oxocyclopent-1-ene-1-carboxylate. The key steps are a Sharpless asymmetric epoxidation and Ti(III)-mediated reductive epoxide opening-radical cyclization to construct the chiral quaternary carbon stereocenter followed by a very challenging HWE olefination reaction on an 1,3-keto aldehyde and a late stage McMurry olefination using low valent titanium to construct the highly constrained angular tetrasubstituted olefin in a five-membered ring.
More Related Videos
Related Concept Videos
Synthetic Biology
Golden rice
Golden rice is a genetically modified...
ATP and Macromolecule Synthesis
Most macromolecules are composed of single subunits, or building blocks, called monomers. The monomers combine with each other using covalent bonds to form larger molecules known as polymers.
Conversion of...
Insulin: Biosynthesis, Chemistry, and Preparation
Damage or functional impairment of β-cells inhibits insulin production, leading to diabetes. Diabetes treatment...
Peptidoglycan Synthesis
Biosynthesis of Nucleic Acids
Biosynthesis of Polysaccharides

