Continuous capture scale down model: A comparison of a continuous and a discrete approach
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Updated: Nov 16, 2025

Modeling the Size Spectrum for Macroinvertebrates and Fishes in Stream Ecosystems
Published on: July 30, 2019
Jonathan C Seidel1, Mathias Göbel1, Rui C Dos Reis Rodrigues2
1Novartis Pharma AG/Global Drug Development - Biopharmaceutical Process Development - Downstream Process Development, Basel, Switzerland.
Abstract:
In continuous pharmaceutical manufacturing, consisting of a perfused batch fermentation and integrated continuous downstream processing, the continuous capture is the linking unit operation. For the development of this unit operation, scale-down models (SDMs) are crucial, whereas discrete, noncontinuous SDMs are preferred over continuous SDM due to their simplistic nature, reduced material consumption, and shorter operation time. The results presented in this study show the suitability of a discrete SDM approach, compared to a continuous SDM for a continuous protein A purification step.
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