Related Experiment Video
Updated: Nov 16, 2025
miRNA Expression Analyses in Prostate Cancer Clinical Tissues
Published on: September 8, 2015
MiRNAs and radical prostatectomy: Current data, bioinformatic analysis and utility as predictors of tumour relapse
Maria Yu Konoshenko1, Pavel P Laktionov1
1Institute of Chemical Biology and Fundamental Medicine, Siberian Branch, Russian Academy of Sciences, Novosibirsk, Russia.
Background:
Studies of microRNAs (miRNAs) and genes have particular interest for cancer biology and medicine due to the discovery of new therapeutic targets and markers. These studies are extensively influenced by anticancer therapy, as miRNAs interfere with the therapy's efficacy in prostate cancer (PCa).
Objectives:
In this article, we summarise the available data on the influence of radical prostatectomy (RP) and biochemical recurrence on miRNA expression.
Materials And Methods:
Molecular targets of these miRNAs, as well as the reciprocal relations between different miRNAs and their targets, were studied using the DIANA, STRING and TransmiR databases. Special attention was dedicated to the mechanisms of PCa development, miRNA, and associated genes as tumour development mediators.
Results And Discussion:
Combined analysis of the databases and available literature indicates that expression of four miRNAs that are associated with prostate cancer relapse and alter their expression after RP, combined with genes that closely interact with selected miRNAs, has high potential for the prediction of PCa relapse after RP. PCa tissues and biofluids, both immediately after RP for diagnostics/prognostics and in long-term (relapse) monitoring, may be used as sources of these miRNAs.
Conclusion:
An overview of the usefulness of published data and bioinformatics resources looking for diagnostic markers and molecular targets is presented in this article. The selected miRNA and gene panels have good potential as prognostic and PCa relapse markers after RP and likely could also serve as markers for therapeutic efficiency on a broader scale.
Insights
Four microRNAs (miRNAs) and interacting genes show promise for predicting prostate cancer (PCa) relapse after radical prostatectomy (RP). These biomarkers can aid in early diagnosis and long-term monitoring of PCa.
Area of Science:
- Oncology
- Molecular Biology
- Genetics
Background:
- MicroRNAs (miRNAs) and genes are crucial in cancer biology, offering potential therapeutic targets and markers.
- miRNAs significantly influence anticancer therapy efficacy, particularly in prostate cancer (PCa).
Purpose of the Study:
- To summarize data on how radical prostatectomy (RP) and biochemical recurrence affect miRNA expression in PCa.
- To identify potential miRNA and gene biomarkers for predicting PCa relapse after RP.
Main Methods:
- Utilized DIANA, STRING, and TransmiR databases to study miRNA molecular targets and their interactions.
- Analyzed reciprocal relations between miRNAs and their targets, focusing on PCa development mechanisms.
Main Results:
- Identified four specific miRNAs whose expression changes post-RP are linked to PCa relapse.
- Found that these miRNAs, along with interacting genes, show high potential for predicting PCa relapse after RP.
- PCa tissues and biofluids are suitable sources for these miRNA biomarkers for diagnostics and monitoring.
Conclusions:
- Selected miRNA and gene panels demonstrate significant potential as prognostic and relapse markers for PCa post-RP.
- These biomarkers may also serve as indicators of therapeutic efficiency on a wider scale.
