Reduced bladder capacity without daytime voiding symptoms with nocturnal enuresis

Area of Science:

• Pediatric Urology
• Pediatric Nephrology
• Child Health

Background:

• Primary nocturnal enuresis (NE) is common in children.
• Monosymptomatic nocturnal enuresis (MSNE) is a subtype of NE.
• Reduced bladder capacity is a potential contributing factor in NE.

Purpose of the Study:

• To determine the prevalence of reduced bladder capacity in children with primary NE.
• To evaluate treatment outcomes for MSNE with reduced bladder capacity.

Main Methods:

• Retrospective evaluation of 54 children newly diagnosed with primary NE.
• Reduced bladder capacity defined by maximal voided volume (MVV) ≤75% of estimated functional bladder capacity.
• Exclusion of daytime lower urinary tract symptoms (LUTS).

Main Results:

• 27.8% of children with primary NE had reduced bladder capacity without daytime LUTS.
• Fifteen children received anticholinergics or beta-3 agonists.
• MVV significantly increased by 56% after three months of medication (P=0.010).
• Complete or partial improvement in enuresis was observed in 66.7% of participants.

Conclusions:

• Reduced bladder capacity is prevalent in children with primary NE, even without daytime voiding symptoms.
• Frequency-volume charts are recommended for diagnosing reduced bladder capacity in primary MSNE.
• Anticholinergics or beta-3 agonists are effective treatments for increasing bladder capacity in MSNE.