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Related Concept Videos

Skin Diseases and Disorders01:23

Skin Diseases and Disorders

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Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
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Changes in Skin Color: Clinical Perspectives01:14

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The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
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Asthma: Pathogenesis and Management01:20

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Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
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Pigmentation01:19

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The color of the skin is influenced by a number of pigments, including melanin, carotene, and hemoglobin. Recall that melanin is produced by cells called melanocytes, which are found scattered throughout the stratum basale of the epidermis. The melanin is transferred to the keratinocytes via melanosomes.
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Asthma-II: Pathophysiology and Classification01:26

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Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
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Chronic Obstructive Pulmonary Disease-II: Pathophysiology01:20

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Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
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Related Experiment Video

Updated: Nov 16, 2025

Granulocyte-dependent Autoantibody-induced Skin Blistering
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Erythroderma (exfoliative dermatitis). Part 1: underlying causes, clinical presentation and pathogenesis.

S Tso1, F Satchwell1, H Moiz2

  • 1Jephson Dermatology Centre, South Warwickshire NHS Foundation Trust, Warwick, UK.

Clinical and Experimental Dermatology
|February 27, 2021
PubMed
Summary

Erythroderma, or exfoliative dermatitis, is an inflammatory skin condition causing barrier and metabolic issues. This review covers its causes, presentation, and potential treatments for unknown cases.

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Area of Science:

  • Dermatology
  • Internal Medicine

Background:

  • Erythroderma (exfoliative dermatitis) is a severe inflammatory skin condition.
  • It affects skin barrier function and metabolism, with an incidence of 1-2 per 100,000 in Europe.
  • Cases can be congenital, acute, or insidious, often arising from chronic dermatoses or malignancy.

Purpose of the Study:

  • To review the underlying causes, clinical presentation, and pathogenesis of erythroderma.
  • To discuss the investigation methods for diagnosing erythroderma.
  • To suggest potential treatment targets for erythroderma cases with unknown etiologies.

Main Methods:

  • Literature review of erythroderma causes, presentation, and pathogenesis.
  • Analysis of diagnostic approaches and investigation strategies.
  • Exploration of therapeutic targets for idiopathic erythroderma.

Main Results:

  • Erythroderma is frequently associated with pre-existing chronic dermatological conditions.
  • A broad range of underlying pathologies, including malignancy, can lead to erythroderma.
  • Investigation involves identifying primary causes and assessing systemic involvement.

Conclusions:

  • Understanding the diverse etiologies of erythroderma is crucial for effective management.
  • Further research into pathogenesis may reveal novel therapeutic targets.
  • A systematic approach to investigation aids in diagnosing the underlying cause of erythroderma.