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Updated: Nov 16, 2025
Comprehensive DNA Methylation Analysis Using a Methyl-CpG-binding Domain Capture-based Method in Chronic Lymphocytic Leukemia Patients
Published on: June 16, 2017
Metagenomic next-generation sequencing (mNGS) for diagnostically challenging infectious diseases in patients with
Marcia Garnica1, Ligia Camera Pierrotti2, Paula Vanessa de Oliveira3
1Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil; Complexo Hospitalar de Niterói, Niterói, RJ, Brazil.
Abstract:
This report shows the contribution of next-generation metagenomic sequencing (mNGS) as an alternative to challenging diagnostic infection in immunosuppressed individuals. Herein, we report three acute leukemia patients who developed severe invasive infections due to different etiologies: fungi, viruses, and protozoa. mNGS improved the diagnosis of the infections and provided the opportunity for adequate therapy. The mNGS is a hypothesis-free diagnostic platform, increasing potential in challenging diseases in hematological patients due to the extended diagnostic panel and the expedite access to the result.
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