Age and multimorbidities as poor prognostic factors for COVID-19 in hemodialysis: a Lebanese national study

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Mabel Aoun1,2, Rabab Khalil3, Walid Mahfoud4

  • 1Department of Nephrology, Saint-George Hospital Ajaltoun, Ajaltoun, Lebanon. aounmabel@yahoo.fr.

BMC Nephrology
|February 28, 2021
PubMed

Insights

Older age, heart failure, coronary artery disease, multimorbidities, fever, and pneumonia increase mortality risk for hemodialysis patients with COVID-19. This national study found a 23.8% death rate, comparable to international figures.

Area of Science:

  • Nephrology
  • Infectious Diseases
  • Public Health

Background:

  • Patients undergoing chronic hemodialysis face elevated mortality risk from COVID-19 compared to the general population.
  • Previous research identified prognostic factors in Asian, European, and American populations.
  • This study represents the first national investigation in Lebanon on SARS-CoV-2 mortality factors in hemodialysis patients.

Purpose of the Study:

  • To identify demographic, comorbidity, and clinical factors associated with mortality in Lebanese hemodialysis patients diagnosed with SARS-CoV-2.
  • To provide a national perspective on risk factors for COVID-19 related deaths in this vulnerable patient group.

Main Methods:

  • An observational study was conducted on chronic hemodialysis patients in Lebanon who tested positive for SARS-CoV-2 between March 31 and November 1, 2020.
  • Retrospective data collection included demographics, comorbidities, hospitalization details, and outcomes from patient medical records.
  • Binary logistic regression analysis was employed to determine risk factors for mortality.

Main Results:

  • The study included 231 patients with a mean age of 61.46 years; 52.8% were male.
  • A significant mortality rate of 23.8% was observed, with a median time to death of 6 days.
  • Adjusted analysis revealed increased mortality risk associated with older age, heart failure, coronary artery disease, multimorbidities, fever, high CRP levels, and pneumonia.

Conclusions:

  • Older age, heart failure, coronary artery disease, multimorbidities, fever, and pneumonia are significant risk factors for death in Lebanese hemodialysis patients with COVID-19.
  • The observed 23.8% mortality rate in this cohort is comparable to rates reported in other countries.
  • Findings underscore the need for targeted preventive and therapeutic strategies for high-risk hemodialysis patients during the COVID-19 pandemic.
Abstract

Keywords:
COVID-19HemodialysisMortalityMultimorbiditiesNational studySARS-CoV-2

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